The Polyphyletic Origins of Primase-Helicase Bifunctional Proteins
| Autor: | Ankita Gupta, Supriya Deepak Patil, Ramya Vijayakumar, Kiran Kondabagil |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DNA Replication Models Molecular Virophages Bacterial genome size DNA Primase Genome Evolution Molecular 03 medical and health sciences chemistry.chemical_compound Viral Proteins Protein Domains Genetics Bifunctional Databases Protein Molecular Biology Ecology Evolution Behavior and Systematics Phylogeny biology Virophage DNA Helicases DNA Viruses Helicase Eukaryota 030104 developmental biology chemistry Horizontal gene transfer biology.protein Primase |
| Zdroj: | Journal of molecular evolution. 85(5-6) |
| ISSN: | 1432-1432 |
| Popis: | We studied the evolutionary relationships of different primase–helicase bifunctional proteins, found mostly in viruses, virophages, plasmids, and organellar genomes, by phylogeny and correlation analysis. Our study suggests independent origins of primase–helicase bifunctional proteins resulting from multiple fusion events between genes encoding primase and helicase domains of different families. The correlation analysis further indicated strong functional dependencies of domains in the bifunctional proteins that are part of smaller genomes and plasmids. Bifunctional proteins found in some bacterial genomes exhibited weak coevolution probably suggesting that these are the non-functional remnants of the proteins acquired via horizontal transfer. We have put forward possible scenarios for the origin of primase–helicase bifunctional proteins in large eukaryotic DNA viruses and virophages. |
| Databáze: | OpenAIRE |
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