In silico prediction of drug safety: despite progress there is abundant room for improvement

Autor:	Peter D. J. Grootenhuis, Gregor Zlokarnik, William J. Egan
Rok vydání:	2004
Předmět:	Drug Cardiotoxicity Liver toxicity business.industry media_common.quotation_subject In silico Drug Discovery Molecular Medicine Medicine Pharmacology business Bioinformatics media_common
Zdroj:	Drug Discovery Today: Technologies. 1:381-387
ISSN:	1740-6749
DOI:	10.1016/j.ddtec.2004.11.002
Popis:	Predictive models for drug safety are crucial for helping to avoid costly late-stage failures. We review recent work on models for genotoxicity, liver toxicity, CYP450 inhibition and cardiotoxicity. These models have improved somewhat in recent years, and research has expanded into new frontiers, such as the prediction of liver toxicity. However, much more needs to be done.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062622488445d5d77e7f9140b1a2ef99 https://doi.org/10.1016/j.ddtec.2004.11.002 Zobrazit plný text záznamu Full Text from ScienceDirect