A New Modular and Practical Methodology for the Synthesis of 4- or 3-Substituted Phenyl C-Nucleosides

Autor:	Michal Hocek, Blanka Klepetarova, Radek Pohl
Rok vydání:	2005
Předmět:	C glycosides business.industry Chemistry Stereochemistry Organic Chemistry General Medicine Modular design Combinatorial chemistry Coupling reaction Coupling (electronics) Nucleic acid Epimer C nucleosides Physical and Theoretical Chemistry business Nucleoside
Zdroj:	European Journal of Organic Chemistry. 2005:4525-4528
ISSN:	1099-0690 1434-193X
Popis:	A novel efficient and practical approach to the synthesis of 4- or 3-substituted phenyl C-nucleosides has been developed. It consists in coupling of protected halogenose 1 with bromophenylmagnesium bromides followed by acid mediated epimerization to prepare 4- or 3-bromophenyl C-nucleoside intermediates. Their Pd-catalyzed cross-coupling reactions with diverse organometallics followed by deprotection afforded the title nucleoside analogues. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0626197294549ab25a0f07f19b28ba63 https://doi.org/10.1002/ejoc.200500607 Zobrazit plný text záznamu Plný text