Optical coherence tomography tissue coverage and characterization at six months after implantation of bioresorbable scaffolds versus conventional everolimus eluting stents in the ISAR-Absorb MI trial
| Autor: | Petra Hoppmann, Karl-Ludwig Laugwitz, Robert A. Byrne, Simon Schneider, Himanshu Rai, Nejva Nano, Michael Joner, Evald Høj Christiansen, Jens Wiebe, Fernando Alfonso, Christian Bradaric, Roisin Colleran, Michael Maeng, Salvatore Cassese, F Harzer, Javier Cuesta, Adnan Kastrati, Jola Bresha |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Target lesion
Bioresorbable scaffold medicine.medical_treatment Everolimus/adverse effects Acute myocardial infarction Coronary Angiography law.invention Grey-scale signal intensity Percutaneous Coronary Intervention Optical coherence tomography Randomized controlled trial law Predictive Value of Tests Absorbable Implants medicine Humans Radiology Nuclear Medicine and imaging Myocardial infarction Everolimus Cardiac imaging METALLIC STENTS Percutaneous Coronary Intervention/adverse effects Original Paper medicine.diagnostic_test business.industry Stent Drug-Eluting Stents Uncovered struts medicine.disease Malapposition RANDOMIZED-TRIAL Treatment Outcome MYOCARDIAL-INFARCTION BIODEGRADABLE POLYMER Angiography VASCULAR SCAFFOLDS Stents Cardiology and Cardiovascular Medicine business Nuclear medicine Tomography Optical Coherence |
| Zdroj: | Rai, H, Alfonso, F, Maeng, M, Bradaric, C, Wiebe, J, Cuesta, J, Christiansen, E H, Cassese, S, Hoppmann, P, Colleran, R, Harzer, F, Bresha, J, Nano, N, Schneider, S, Laugwitz, K-L, Joner, M, Kastrati, A & Byrne, R A 2021, ' Optical coherence tomography tissue coverage and characterization at six months after implantation of bioresorbable scaffolds versus conventional everolimus eluting stents in the ISAR-Absorb MI trial ', The international journal of cardiovascular imaging, vol. 37, no. 10, pp. 2815-2826 . https://doi.org/10.1007/s10554-021-02251-x The International Journal of Cardiovascular Imaging |
| Popis: | Purpose Data regarding vessel healing by optical coherence tomography (OCT) after everolimus-eluting bioresorbable scaffolds (BRS) or everolimus-eluting metallic stent (EES) implantation in acute myocardial infarction (AMI) patients is scarce. We compared OCT findings after BRS or EES implantation in patients with AMI enrolled in a randomized trial. Methods In ISAR-Absorb MI, AMI patients were randomized to BRS or EES implantation, with 6–8 month angiographic follow-up. This analysis includes patients who underwent OCT during surveillance angiography. Tissue characterization was done using grey-scale signal intensity analysis. The association between OCT findings and target lesion failure (TLF) at 2 years was investigated. Results OCT was analyzed in 103 patients (2237 frames, 19,827 struts) at a median of 216 days post-implantation. Of these, 70 were treated with BRS versus 32 with EES. Pre-(92.8 vs. 68.7%, p = 0.002) and post-dilation (51.4 vs. 12.5%, p At two-years, 8 (7.8%) patients experienced TLF. Mean neointimal area [0.61 (0.21, 1.33) vs. 0.41 (0.11, 0.75) mm2, p = 0.03] and mean neointimal coverage [106.1 (65.2, 214.8) vs. 80.5 (53.5, 122.1) µm, p Conclusions In selected patients who underwent OCT surveillance 6–8 months after coronary intervention for AMI with differing implantation characteristics depending on the device type used, vessel healing was more advanced in BRS compared with EES, particularly in the STEMI subgroup. |
| Databáze: | OpenAIRE |
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