Factor V Leiden and Ischemic Stroke Risk: The Genetics of Early Onset Stroke (GEOS) Study
| Autor: | Barney J. Stern, O. C. Stine, Jeffrey R. O'Connell, John W. Cole, Mary J. Sparks, Braxton D. Mitchell, Marcella A. Wozniak, Steven J. Kittner, Ali G. Hamedani, Yu-Ching Cheng |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adolescent Population Risk Assessment Article Brain Ischemia Young Adult Gene Frequency Risk Factors Odds Ratio medicine Factor V Leiden Humans Point Mutation Genetic Predisposition to Disease cardiovascular diseases Age of Onset Risk factor education Blood Coagulation Stroke Activated Protein C Resistance Genetics education.field_of_study Chi-Square Distribution business.industry Rehabilitation Case-control study Factor V Odds ratio Middle Aged medicine.disease Venous thrombosis Logistic Models Phenotype Case-Control Studies Baltimore District of Columbia Female Surgery Neurology (clinical) Age of onset Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Stroke and Cerebrovascular Diseases. 22:419-423 |
| ISSN: | 1052-3057 |
| DOI: | 10.1016/j.jstrokecerebrovasdis.2011.10.007 |
| Popis: | Background Factor V Leiden (FVL) has been associated with ischemic stroke in children but not in adults. Although the FVL mutation is associated with increased risk for venous thrombosis, its association with ischemic stroke in young adults remains uncertain. Therefore, we examined the association between FVL and ischemic stroke in participants of the Genetics of Early Onset Stroke (GEOS) study. Methods A population-based case control study identified 354 women and 476 men 15 to 49 years of age with first-ever ischemic stroke and 907 controls. Participant-specific data included vascular risk factors, FVL genotype and, for cases, the ischemic stroke subtype by modified Trial of ORG 10172 in Acute Stroke criteria. Logistic regression was used to calculate odds ratios for the entire population and for subgroups stratified by risk factors and ischemic stroke subtype. Results The frequency of the FVL mutation was similar between ischemic stroke patients (3.6%; 95% confidence interval [CI] 2.5%-5.1%) and nonstroke controls (3.8%; 95% CI 2.7%-5.2%). This frequency did not change significantly when cases were restricted to patients with stroke of undetermined etiology (4.1%; 95% CI 2.6%-6.4%). Conclusions Among young adults, we found no evidence for an association between FVL and either all ischemic stroke or the subgroup with stroke of undetermined etiology. |
| Databáze: | OpenAIRE |
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