Transcriptional regulation of drug resistance mechanisms in Salmonella: where we stand and what we need to know
| Autor: | Mazhar Iqbal, D. A. Maslov, Aamir Shehzad, Osman Mirza, Moazur Rahman, Anam Tariq, Aqsa Shaheen |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Salmonella typhimurium Physiology Regulator Drug resistance Biology 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences chemistry.chemical_compound Antibiotic resistance Bacterial Proteins Salmonella 010608 biotechnology Drug Resistance Multiple Bacterial Transcriptional regulation TetR Gene Immune Evasion Genetics 0303 health sciences Virulence 030306 microbiology General Medicine Gene Expression Regulation Bacterial Anti-Bacterial Agents Multiple drug resistance chemistry Trans-Activators Efflux Multidrug Resistance-Associated Proteins Carrier Proteins Genome Bacterial Biotechnology Signal Transduction Transcription Factors |
| Zdroj: | World journal of microbiologybiotechnology. 36(6) |
| ISSN: | 1573-0972 |
| Popis: | Salmonellae have evolved a wide range of molecular mechanisms to neutralize the effect of antibiotics and evade the host immune system response. These mechanisms are exquisitely controlled by global and local regulators and enable the pathogens to use its energy as per need and hence allow the pathogen to economize the consumption of energy by its cellular machinery. Several families that regulate the expression of different drug resistance genes are known; some of these are: the TetR family (which affects tetracycline resistance genes), the AraC/XylS family (regulators that can act as both transcriptional activators and repressors), two-component signal transduction systems (e.g. PhoPQ, a key regulator for virulence), mercury resistance Mer-R and multiple antibiotic resistance Mar-R regulators, LysR-type global regulators (e.g. LeuO) and histone-like protein regulators (involved in the repression of newly transferred resistance genes). This minireview focuses on the role of different regulators harbored by the Salmonella genome and characterized for mediating the drug resistance mechanisms particularly via efflux and influx systems. Understanding of such transcriptional regulation mechanisms is imperative to address drug resistance issues in Salmonella and other bacterial pathogens. |
| Databáze: | OpenAIRE |
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