Differential constrictor responses of cephalic and caudal vasculature to α-adrenoceptor agonist after hind limb unloading
| Autor: | Dongzhe SongD. Song, Jong Moo KimJ.M. Kim, Simon R. Hutchings, Catherine C.Y. Pang |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Agonist Physiology medicine.drug_class Hemodynamics Blood Pressure Hindlimb Iliac Artery Methoxamine Constriction Rats Sprague-Dawley Physiology (medical) medicine Animals Lower Body Negative Pressure Pharmacology Dose-Response Relationship Drug business.industry General Medicine Blood flow Anatomy musculoskeletal system Rats Carotid Arteries Blood pressure Hindlimb Suspension Vasoconstriction Cerebrovascular Circulation cardiovascular system medicine.symptom business Adrenergic alpha-Agonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 88:1035-1041 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y10-083 |
| Popis: | We examined the effects of hind limb unloading (HLU, 14 days) on constriction of carotid and iliac arterial beds in vivo in thiobutabarbital-anaesthetized rats and isolated carotid and iliac arteries in vitro. Both control and HLU rats had similar arterial pressure and carotid and iliac arterial flows. The HLU rats had increased carotid arterial but reduced iliac arterial constriction in response to methoxamine (α1-adrenoceptor agonist) in vivo. In contrast, constriction in response to methoxamine was reduced in the isolated carotid and unchanged in the iliac artery of HLU rats relative to control rats. Thus, HLU is associated with increased constriction of carotid arterial bed but reduced constriction of the isolated carotid artery, and reduced constriction of iliac arterial bed but unchanged constriction of the isolated iliac artery. These results show differential influence of HLU on constriction of cephalic and caudal arterial beds, and differential effect on constrictions of arterial beds relative to conduit arteries. |
| Databáze: | OpenAIRE |
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