Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population
Autor: | Tom Bendix, Tue Secher Jensen, Per Kjaer, Claus Manniche, Joan Solgaard Sorensen, Lars Korsholm |
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Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors lcsh:Diseases of the musculoskeletal system Denmark Population Dentistry Lumbar vertebrae Modic forandringer Rheumatology Predictive Value of Tests Lænderyggen Back pain medicine Humans Orthopedics and Sports Medicine Prospective Studies education Intervertebral Disc Lumbar Spine Sciatica Observer Variation education.field_of_study Lumbar Vertebrae business.industry Reproducibility of Results Intervertebral disc Modic changes MR Low back pain Health Surveys Magnetic Resonance Imaging Vertebra Surgery medicine.anatomical_structure Logistic Models Disease Progression Female Spinal Diseases medicine.symptom lcsh:RC925-935 business MRI Research Article |
Zdroj: | BMC Musculoskeletal Disorders, Vol 10, Iss 1, p 81 (2009) BMC Musculoskeletal Disorders Jensen, T S, Bendix, T, Sorensen, J S, Manniche, C, Korsholm, L & Kjaer, P 2009, ' Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population ', BMC Musculoskeletal Disorders, vol. 10, pp. 81 . https://doi.org/10.1186/1471-2474-10-81 |
ISSN: | 1471-2474 |
Popis: | Background Vertebral endplate signal changes (VESC) are more common among patients with low back pain (LBP) and/or sciatica than in people who are not seeking care for back pain. The distribution and characteristics of VESC have been described in people from clinical and non-clinical populations. However, while the clinical course of VESC has been studied in patients, the natural course in the general population has not been reported. The objectives of this prospective observational study were to describe: 1) the distribution and characteristics of VESC in the lumbar spine, 2) its association with disc degeneration, and 3) its natural course from 40 to 44 years of age. Methods Three-hundred-and-forty-four individuals (161 men and 183 women) sampled from the Danish general population had MRI at the age of 40 and again at the age of 44. The following MRI findings were evaluated using standardised evaluation protocols: type, location, and size of VESC, disc signal, and disc height. Characteristics and distribution of VESC were analysed by frequency tables. The association between VESC and disc degeneration was analysed by logistic regression analysis. The change in type and size of VESC was analysed by cross-tabulations of variables obtained at age 40 and 44 and tested using McNemar's test of symmetry. Results Two-thirds (67%) of VESC found in this study were located in the lower part of the spine (L4-S1). VESC located at disc levels L1-L3 were generally small and located only in the anterior part of the vertebra, whereas those located at disc levels L4-S1 were more likely to extend further into the vertebra and along the endplate. Moreover, the more the VESC extended into the vertebra, the more likely it was that the adjacent disc was degenerated. The prevalence of endplate levels with VESC increased significantly from 6% to 9% from age 40 to 44. Again, VESC that was only observed in the endplate was more likely to come and go over the four-year period compared with those which extended further into the vertebra, where it generally persisted. Conclusion The prevalence of VESC increased significantly over the four-year period. Furthermore, the results from this study indicate that the distribution of VESC, its association with disc degeneration and its natural course, is dependent on the size of the signal changes. |
Databáze: | OpenAIRE |
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