Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal
| Autor: | Gianrico Farrugia, Gregory L Lyford |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Potassium Channels Gastrointestinal smooth muscle PDZ domain Motility Biology Ion Channels Sodium Channels symbols.namesake Smooth muscle Drug Discovery medicine Motor activity Ion channel Pharmacology Effector Muscle Smooth Cell biology Interstitial cell of Cajal Electrophysiology Gastrointestinal Tract symbols Calcium Channels Stress Mechanical Gastrointestinal Motility |
| Zdroj: | Current Opinion in Pharmacology. 3:583-587 |
| ISSN: | 1471-4892 |
| DOI: | 10.1016/j.coph.2003.06.010 |
| Popis: | A requirement for normal gastrointestinal motility is the tight regulation of ion channels expressed in interstitial cells of Cajal and smooth muscle. Interstitial cells of Cajal generate the slow wave and amplify neuronal signals; smooth muscle functions as the final effector organ. Recent advances in our understanding of the expression and mechano-regulation of these different subtypes of ion channels have allowed the development of hypotheses on how ion channels transduce a variety of inputs into electrical signals that directly or indirectly regulate gastrointestinal motor activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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