In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology
| Autor: | Adam Meeckings, Lucia Pelosini, Henry B. Smith, John B Schofield, Anish Dhital, Mona Khandwala |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Design modification Pathology medicine.medical_specialty Skin Neoplasms Biopsy Statistics as Topic Pilot Projects Eyelid Neoplasms Positive correlation Cellular and Molecular Neuroscience Optical coherence tomography In vivo Humans Medicine Basal cell carcinoma Prospective Studies Aged Aged 80 and over Fourier Analysis integumentary system medicine.diagnostic_test business.industry Eyelids Histology Middle Aged medicine.disease eye diseases Sensory Systems Ophthalmology Carcinoma Basal Cell Depth of invasion Female sense organs business Tomography Optical Coherence |
| Zdroj: | British Journal of Ophthalmology. 97:890-894 |
| ISSN: | 1468-2079 0007-1161 |
| Popis: | Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC). Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The vertical margin correlation was r=0.43 and BCC depth could be measured in 9/15 cases. The following histological features of BCC could be identified on OCT images: (1) lobular pattern (100%); (2) dilated blood vessels (80%); (3) reflective margins of tumour lobules (100%); and (4) epidermal thinning overlying BCC lobules (100%). Conclusions This study indicated a strong positive correlation between the margins of periocular BCCs measured using in vivo OCT and histology, and a weak positive correlation with depth of invasion. VivoSight OCT produced high resolution images of BCC morphology. The limitations in horizontal margin measurements could potentially be overcome by design modification of the scanning probe. |
| Databáze: | OpenAIRE |
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