13C-31P Couplings in the Study of Conformational Properties of Some Diastereomeric Nucleoside-3′-Thiophosphate Derivatives

Autor:	Gyula Sági, Mária Kajtár-Peredy, Eszter Gács-Baitz
Rok vydání:	2005
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Molecular Conformation Electrons Biochemistry Mass Spectrometry Phosphates Thiophosphate chemistry.chemical_compound Genetics Carbon Isotopes Chromatography Chemistry Temperature Diastereomer Phosphorus Isotopes Nucleosides Phosphorus Stereoisomerism General Medicine Carbon Solvent Models Chemical Nucleic Acid Conformation Molecular Medicine Nucleoside Vicinal
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 24:247-257
ISSN:	1532-2335 1525-7770
Popis:	Synthesis and stereochemical characterization of enantiomerically pure nucleoside-3'-phosphorothioate esters and salts are reported. Vicinal carbon phosphorus couplings reflect different predominance of the epsilon conformation in the isomeric (Rp and Sp) esters, while for the salts the epsilont conformation prevails in both stereoisomers. The influence of solvent and temperature on the conformational preferences is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061da0973ba66a561544b5835c015249 https://doi.org/10.1081/ncn-59691 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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