The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved
| Autor: | Laura Croce, Luca Chiovato, Mario Rotondi, Gianluca Ricci, Francesca Coperchini, Flavia Magri |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
IL-17 interleukin-17 Chemokine IL-1 interleukin-1 medicine.medical_treatment Endocrinology Diabetes and Metabolism CCL20 C-C Motif Chemokine Ligand 20 CCL3 C-C Motif Chemokine Ligand 3 Disease RNA-Seq RNA sequencing CXCL8 C-X-C Motif Chemokine Ligand 8 Bioinformatics Chemokine receptor 0302 clinical medicine MERS-CoV middle east respiratory syndrome coronavirus Pandemic BALF bronchoalveolar lavage fluid Medicine Immunology and Allergy IFN-γ interferon-γ IL-6 interleukin-6 CXCL8 - cytokine storm scRNA-seq single-cell RNA sequencing CXCL9 C-X-C Motif Chemokine Ligand 9 biology CXCL10 TNFα tumor-necrosis-factor- α CS cytokine storm ICU intensive care unit ACE-2 angiotensin-converting enzyme-2 Cytokine release syndrome Cytokine 030220 oncology & carcinogenesis Cytokines Chemokines Cytokine Release Syndrome JAK Janus kinase PBMC peripheral blood mononuclear cell ATP adenosine triphosphate Mini Review Immunology CXCL10 C-X-C Motif Chemokine Ligand 10 General Biochemistry Genetics and Molecular Biology 03 medical and health sciences IL1β interleukin-1 β HIV-1-2 human immunodeficiency virus-1-2 CXCL1 C-X-C Motif Chemokine Ligand 1 Humans GSCF granulocyte colony-stimulating factor CCL2 C-C Motif Chemokine Ligand 2 CCL5 C-C Motif Chemokine Ligand 5 ARDS acute respiratory distress syndrome Covid-19 coronavirus disease 2019 CCL19 C-C Motif Chemokine Ligand 19 business.industry SARS-CoV-2 COVID-19 ssGSEA single sample gene set enrichment analysis medicine.disease Th17 T-Helper-17 CXCR3 CXC-chemokine receptor 3 030104 developmental biology biology.protein SARS-COV-2 severe acute respiratory syndrome coronavirus 2 MIS-C multisystem inflammatory syndrome in children business Cytokine storm COVID-19-coronavirus |
| Zdroj: | Cytokine & Growth Factor Reviews |
| ISSN: | 1879-0305 |
| Popis: | SARS-COV-2 infection represents the greatest pandemic of the world, counting daily increasing number of subjects positive to the virus and, sadly, increasing number of deaths. Current studies reported that the cytokine/chemokine network is crucial in the onset and maintenance of the "cytokine storm", the event occurring in those patients in whom the progression of COVID-19 will progress, in most cases, to a very severe and potentially threatening disease. Detecting a possible "immune signature" in patients, as assessed by chemokines status in patients with COVID-19, could be helpful for individual risk stratification for developing a more or less severe clinical course of the disease. The present review is specifically aimed at overviewing current evidences provided by in vitro and in vivo studies addressing the issue of which chemokines seems to be involved, at least at present, in COVID-19. Currently available experimental and clinical studies regarding those chemokines more deeply studied in COVID-19, with a specific focus on their role in the cytokine storm and ultimately with their ability to predict the clinical course of the disease, will be taken into account. Moreover, similarities and differences between chemokines and cytokines, which both contribute to the onset of the pro-inflammatory loop characterizing SARS-COV-2 infection, will be briefly discussed. Future studies will rapidly accumulate in the next months and their results will hopefully provide more insights as to the complex physiopathology of COVID-19-related cytokine storm. This will likely make the present review somehow "dated" in a short time, but still the present review provides an overview of the scenario of the current knowledge on this topic. |
| Databáze: | OpenAIRE |
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