Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database
| Autor: | Jianshu Hu, Yan Wang, David Chi-Cheong Wan, Huangquan Lin, Chu Ying Xiao, Tsz Ming Ip, Wai Kit Law |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Virtual screening Nutrition and Dietetics Natural product Adipogenesis Flavonols Nutrition. Foods and food supply Medicine (miscellaneous) Hyperoside Biology Peroxisome Pharmacology Fatty acid-binding protein 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Fatty acid binding protein 4 inhibitor chemistry Biochemistry Adipocyte TX341-641 Receptor Food Science |
| Zdroj: | Journal of Functional Foods, Vol 20, Iss, Pp 159-170 (2016) |
| ISSN: | 1756-4646 |
| Popis: | The inhibition of fatty acid binding protein 4 (FABP4) by using small molecules could potentially provide therapeutic opportunities for metabolic disorders treatment. According to the results of our in-house virtual screening on the herbal molecules database, this study reports flavonols as an ideal scaffold for FABP4 inhibitors development. Among the popular flavonols examined, we identified hyperoside as a promising FABP4 inhibitor. Identical to the well-known FABP4 inhibitor BMS309403, hyperoside induced lipid accumulation and upregulated peroxisome proliferator-activated receptor γ (PPARγ) protein expression during the adipocyte differentiation process. Furthermore, both PPARγ antagonist and FABP4 overexpression attenuated hyperoside-induced adipogenesis, indicating that hyperoside promoted adipogenesis in adipocytes via the FABP4/PPARγ pathway. We anticipate hyperoside to be a promising, novel FABP4 inhibitor for antidiabetic drug development. |
| Databáze: | OpenAIRE |
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