Economic burden of multiple sclerosis in a population with low physical disability
| Autor: | Garcia-Dominguez, Jose M., Maurino, Jorge, Martinez-Gines, Maria L., Carmona, Olga, Caminero, Ana B., Medrano, Nicolas, Ruiz-Beato, Elena, Ares, Adrian, Arnal, Carmen, Carcelen, Maria, Eguia, Pablo, del Carmen Fernandez, Maria, Ginestal, Ricardo, Lacruz, Laura, Llaneza, Miguel, Lopez de Silanes, Carlos, Martin, Gisela, Navarro, Laura, Romero, Beatriz, Seral, Maria, Solar, Myriam, W-IMPACT Clinical Investigators |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
esclerosis múltiple medicine.medical_specialty Physical disability humanos Population coste de las enfermedades 030209 endocrinology & metabolism jubilación Multiple sclerosis 03 medical and health sciences Indirect costs 0302 clinical medicine Cost of Illness Interquartile range Absenteeism medicine Humans 030212 general & internal medicine Burden of illness education mediana edad Retirement education.field_of_study Expanded Disability Status Scale Disability business.industry Public health lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Middle Aged adulto Caregiver Costs Cross-Sectional Studies absentismo laboral Sick leave business estudios transversales Demography Research Article |
| Zdroj: | BMC Public Health BMC Public Health, Vol 19, Iss 1, Pp 1-8 (2019) |
| ISSN: | 1471-2458 |
| Popis: | BackgroundIn multiple sclerosis (MS), half of affected people are unemployed within 10years of diagnosis. The aim of this study was to assess the economic impact of MS in adult subjects with relapsing-remitting MS (RRMS) and primary progressive MS (PPMS).MethodsA multicenter, non-interventional, cross-sectional study was conducted. The Expanded Disability Status Scale (EDSS) and the 23-item Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) were used to assess disability and work performance, respectively. Only indirect costs were considered using the human capital method, including work costs. Professional support costs and informal caregivers' costs were also estimated.ResultsA total of 199 subjects were studied (mean age: 43.910.5years, 60.8% female, 86.4% with RRMS). Median EDSS score was 2.0 (interquartile range: 1.0-3.5) and median MSWDQ-23 total score was 31.5 (15.2, 50.0). The number of employed subjects decreased after MS diagnosis from 70.6 to 47.2%, and the number of retired people increased (23.6%). Mean age of retirement was 43.6 +/- 10.5years. Ten percent of the population had sick leaves (absenteeism was seen in 90.9% of the student population and 30.9% of the employed population). Professional support in their daily life activities was needed in 28.1% of subjects. Costs for sick leave, work absenteeism, premature retirement and premature work disability/pensioner were Euro416.6 +/- 2030.2, Euro763.4 +/- 3161.8, Euro5810.1 +/- 13,159.0 and Euro1816.8 +/- 9630.7, respectively. Costs for professional support and informal caregiving activities were Euro1026.93 +/- 4622.0 and Euro1328.72, respectively.Conclusions p id=Par4 MS is responsible for a substantial economic burden due to indirect and informal care costs, even in a population with low physical disability. The study was funded by Roche Farma, Spain (ML39424). The sponsor was involved in the design, execution, analysis, and interpretation of the results. |
| Databáze: | OpenAIRE |
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