Early lung retrieval from traumatic brain-dead donors does not compromise outcomes following lung transplantation
| Autor: | Carlos Baamonde, Francisco Javier Algar, Francisco Cerezo, Antonio Alvarez, Dionisio Espinosa, Paula Moreno, Jennifer Illana, A. Salvatierra |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Brain Death medicine.medical_specialty Adolescent Cystic Fibrosis Pulmonary Fibrosis medicine.medical_treatment Bronchiolitis obliterans Primary Graft Dysfunction Kaplan-Meier Estimate Lung injury Gastroenterology Pulmonary Disease Chronic Obstructive Internal medicine medicine Humans Lung transplantation Bronchiolitis Obliterans Lung Retrospective Studies Analysis of Variance Chi-Square Distribution Bronchiectasis business.industry General Medicine Perioperative Middle Aged medicine.disease Tissue Donors Surgery Transplantation Treatment Outcome medicine.anatomical_structure Wounds and Injuries Female Cardiology and Cardiovascular Medicine business Lung Transplantation |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 43:e190-e197 |
| ISSN: | 1873-734X 1010-7940 |
| DOI: | 10.1093/ejcts/ezt033 |
| Popis: | OBJECTIVES: To determine whether lung retrieval from traumatic donors performed within 24 h of brain death has a negative impact on early graft function and survival after lung transplantation (LT), when compared with those retrieved after 24 h. METHODS: Review of lung transplants performed from traumatic donors over a 17-year period. Recipients were distributed into two groups: transplants from traumatic donor lungs retrieved within 24 h of brain death (Group A), and transplants from traumatic donor lungs retrieved after 24 h of brain death (Group B). Demographic data of donors and recipients, early graft function, perioperative complications and mortality were compared between both groups. RESULTS: Among 356 lung transplants performed at our institution, 132 were from traumatic donors (70% male, 30% female). Group A: 73 (55%); Group B: 59 (45%). There were 53 single, 77 double, and 2 combined LT. Indications were emphysema in 41 (31%), pulmonary fibrosis in 31 (23%), cystic fibrosis in 38 (29%), bronchiectasis in 9 (7%) and other indications in 13 patients (10%). Donor and recipient demographic data, need or cardiopulmonary bypass, postoperative complications and Intensive Care Unit and hospital stay did not differ between groups. Primary graft dysfunction (A vs B): 9 (16%) vs 13 (26%) P= 0.17. PaO2/FiO2 24 h post-transplant (A vs B): 303 mmHg vs 288 mmHg (P= 0.57). Number of acute rejection episodes (A vs B): 0.93 vs 1.49 (P= 0.01). Postoperative intubation time (A vs B): 99 vs 100 h (P= 0.99). 30-day mortality (A vs B): 7 (10%) vs 2 (3.5%) (P= 0.13). Freedom from bronchiolitis obliterans syndrome (A vs B): 82, 72, 37, 22 vs 78, 68, 42, 15%, at 3, 5, 10 and 15 years, respectively (P= 0.889). Survival (A vs B): 65, 54, 46, 42 and 27 vs 60, 50, 45, 43 and 29% at 3, 5, 7, 10 and 15 years, respectively (P= 0.937). CONCLUSIONS: In our experience, early lung retrieval after brain death from traumatic donors does not adversely affect early and long-term outcomes after LT. |
| Databáze: | OpenAIRE |
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