Cyano-Sacrificial (Arylthio)arylamination of Quinoline and Isoquinoline N-Oxides Using N-(2-(Arylthio)aryl)cyanamides

Autor:	Ahalya Behera, Ashish Kumar Sahoo, Bhisma K. Patel, Prasenjit Sau
Rok vydání:	2018
Předmět:	010405 organic chemistry Aryl Organic Chemistry Quinoline Regioselectivity chemistry.chemical_element 010402 general chemistry 01 natural sciences Medicinal chemistry Reductive amination Copper 0104 chemical sciences chemistry.chemical_compound chemistry Isoquinoline
Zdroj:	The Journal of organic chemistry. 83(18)
ISSN:	1520-6904
Popis:	A copper(I)-catalyzed regioselective arylthio-arylamination of quinoline and isoquinoline N-oxides has been achieved at the expense of a cyano (CN) group from N-(2-(arylthio)aryl)cyanamides. This reductive amination proceeds in one pot at 80 °C in the absence of any additives. This is a unique demonstration of aryl cyanamides serving as arylaminating agents on quinoline/isoquinoline N-oxides with concurrent autoreduction of N-oxide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06157dc144b460db0eb01e761ee6331e https://pubmed.ncbi.nlm.nih.gov/30102040 Zobrazit plný text záznamu