Hyperpolarized 3He MR for Sensitive Imaging of Ventilation Function and Treatment Efficiency in Young Cystic Fibrosis Patients with Normal Lung Fonction
| Autor: | Philippe Reix, Sophie Gaillard, Françoise Aubert, Karim Mosbah, Elise Bannier, Yannick Crémillieux, Yves Berthezène, François Duboeuf, Katarzyna Cieslar, Zahir Salhi |
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| Přispěvatelé: | Instituto de Tecnologia Ceramica, Universitat Jaume I, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Economie et de Sociologie Rurales Appliquées à l'Agriculture et aux Espaces Ruraux (CESAER), Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Hospices Civils de Lyon (HCL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique (CIC), Centre d'Investigation Clinique, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Service de Pédiatrie, Pneumologie, Allergologie et Mucoviscidose, Hôpital Femme Mère Enfant, European Project: 36297,PHELINET, Bannier, Elise, Polarized HElium Lung Imaging NETwork - PHELINET - 36297 - OLD, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Johannes Gutenberg - Universität Mainz (JGU) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology Pancreatic disease imagerieₚoumons Cystic Fibrosis [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging MESH: Respiratory Function Tests MESH: Pulmonary Ventilation Cystic fibrosis Helium 030218 nuclear medicine & medical imaging MESH: Magnetic Resonance Imaging MESH: Helium 0302 clinical medicine Isotopes MESH: Airway Obstruction imagerieₚulmonaire MESH: Child Stage (cooking) Young adult Child ComputingMilieux_MISCELLANEOUS MESH: Treatment Outcome MESH: Statistics Nonparametric MESH: Respiratory Therapy Respiratory disease MESH: Administration Inhalation Magnetic Resonance Imaging 3. Good health Respiratory Function Tests MESH: Reproducibility of Results reseau_international Treatment Outcome Breathing [SDV.IB]Life Sciences [q-bio]/Bioengineering Female categₘixte Radiology medicine.symptom medicine.medical_specialty Respiratory Therapy MESH: Isotopes MESH: Cystic Fibrosis Adolescent imagerieₘethodologie_RMN Asymptomatic Sensitivity and Specificity Statistics Nonparametric 03 medical and health sciences Administration Inhalation medicine Humans Radiology Nuclear Medicine and imaging MESH: Adolescent [SDV.IB] Life Sciences [q-bio]/Bioengineering MESH: Humans business.industry Reproducibility of Results Normal lung function medicine.disease MESH: Male MESH: Sensitivity and Specificity Airway Obstruction 030228 respiratory system business Pulmonary Ventilation MESH: Female |
| Zdroj: | Radiology Radiology, Radiological Society of North America, 2010 Radiology, 2010, 255 (1), pp.225-32. ⟨10.1148/radiol.09090039⟩ Radiology, Radiological Society of North America, 2010, 255 (1), pp.225-32. ⟨10.1148/radiol.09090039⟩ |
| ISSN: | 0033-8419 1527-1315 |
| DOI: | 10.1148/radiol.09090039⟩ |
| Popis: | International audience; PURPOSE: To assess the sensitivity of hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging for the detection of peripheral airway obstruction in younger cystic fibrosis (CF) patients showing normal spirometric results (mean forced expiratory volume in 1 second [FEV(1)], 112% +/- 14.5 [standard deviation]) and to observe the immediate effects of a single chest physical therapy (CPT) session, thereby comparing two image quantification techniques. MATERIALS AND METHODS: Ten pediatric CF patients (age range, 8-16 years) with normal spirometric results were included in this study after approval from the local research ethics committee. Spirometry followed by proton and hyperpolarized (3)He three-dimensional lung imaging were performed with a 1.5-T MR unit before and after 20 minutes of CPT. The number of ventilation defects per image (VDI) and the ventilated lung fraction (VF), defined as the ratio of ventilated lung volume divided by total lung volume, were quantified. RESULTS: Ventilation defects were found in all patients (mean VDI, 5.1 +/- 1.9; mean global VF, 78.5% +/- 12.3; and mean peripheral VF, 75.5% +/- 17.1) despite normal spirometric results. After CPT, disparate changes in the distribution of ventilation defects were observed but the average VDI and VF did not change significantly (mean VDI, 5.1 +/- 1.1; mean global VF, 83.5% +/- 12.2; and mean peripheral VF, 80.3% +/- 12.2). There was no correlation between FEV(1) and VDI (rho = -0.041, P = .863) or global VF (rho = -0.196, P = .408) values but peripheral VF and VDI were correlated (rho = -0.563, P = .011). CONCLUSION: Although spirometric results indicate normal lung function, the mean VDI in patients (5.1) found in this study is well above the VDI in healthy subjects (1.6) reported in the literature. A single CPT session induces disparate changes in the distribution and extent of ventilation defects. |
| Databáze: | OpenAIRE |
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