Identification of a novel target of D/V signaling in Drosophila wing disc: Wg-independent function of the organizer
| Autor: | Bernd Stadelmayer, Nagraj Sambrani, L. S. Shashidhara, Ruchi Bajpai |
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| Rok vydání: | 2004 |
| Předmět: |
animal structures
Wnt1 Protein Biology Proto-Oncogene Proteins Genetics Animals Drosophila Proteins Wings Animal Drosophila (subgenus) Molecular Biology Psychological repression Gene Ultrabithorax Body Patterning Homeodomain Proteins Wing Organizers Embryonic RNA-Binding Proteins biology.organism_classification Cell biology embryonic structures Drosophila Homeotic gene Function (biology) Biomarkers Developmental Biology Morphogen Transcription Factors |
| Zdroj: | Gene expression patterns : GEP. 5(1) |
| ISSN: | 1567-133X |
| Popis: | Growth and patterning during Drosophila wing development are mediated by signaling from its dorso-ventral (D/V) organizer. Wingless is expressed in the D/V boundary and functions as a morphogen to activate target genes at a distance. Wingless pathway and thereby D/V signaling is negatively regulated by the homeotic gene Ultrabithorax (Ubx) to mediate haltere development. In an enhancer-trap screen to identify genes that show differential expression between wing and haltere discs, we identified CG32062, which codes for a RNA-binding protein. In wing discs, CG32062 is expressed only in non-D/V cells. CG32062 expression in non-D/V cells is dependent on Notch-mediated signaling from the D/V boundary. However, CG32062 expression is independent of Wingless function, thus providing evidence for a second long-range signaling mechanism of the D/V organizer. In haltere discs, CG32062 is negatively regulated by Ubx. The non-cell autonomous nature of Ubx-mediated repression of CG32062 expression suggests that the novel component of D/V signaling is also negatively regulated during haltere specification. |
| Databáze: | OpenAIRE |
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