Transfer of single dose of intravitreal injection of ranibizumab and bevacizumab into milk of sheep
| Autor: | Levent Tok, Cakmak Argun T, Argun M, Alime Gunes, Gulsen Yilmaz, Meric Yilmaz F, Butuner O, Yalcin Tok O |
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| Rok vydání: | 2017 |
| Předmět: |
genetic structures
Bevacizumab lactation bevacizumab 03 medical and health sciences Elisa kit chemistry.chemical_compound 0302 clinical medicine Animal science lcsh:Ophthalmology Lactation Medicine ranibizumab milk vascular endothelial growth factor business.industry Model study Vascular endothelial growth factor Ophthalmology Basic Research medicine.anatomical_structure chemistry lcsh:RE1-994 030221 ophthalmology & optometry Ranibizumab business medicine.drug |
| Zdroj: | International Journal of Ophthalmology, Vol 10, Iss 7, Pp 1069-1075 (2017) |
| ISSN: | 2227-4898 2222-3959 |
| DOI: | 10.18240/ijo.2017.07.08 |
| Popis: | AIM: To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS: This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points. Serum and milk concentrations of bevacizumab and ranibizumab were measured using an enzyme-linked immunosorbent assay (ELISA) kit. The limit of determination was 0.9 ng/mL for bevacizumab and 0.62 ng/mL for ranibizumab. RESULTS: At 6h after intravitreal injections, bevacizumab concentration was above the limit of determination in the blood of all sheep. At 3wk, when the study was terminated, bevacizumab concentrations were high in 4 sheep. Even though bevacizumab concentrations in milk showed fluctuations, the drug transferred into the milk of all sheep at detectable concentrations. Ranibizumab drug concentrations in the blood and milk of sheep and those in the blood of lambs were below the limit of determination by the ELISA kit. CONCLUSION: This sheep model study demonstrate that intravitreal injection of ranibizumab, which did not transfer into the milk of sheep and suckling lambs, is safer than bevacizumab during lactation period. |
| Databáze: | OpenAIRE |
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