Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis
| Autor: | Jameel M.A. Abduljalil |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Riboswitch RNA thermometer Aptamer lcsh:QH426-470 030106 microbiology SD Shine-Dalgarno Computational biology Biology ORFs open reading frames Biochemistry Article RNAP RNA polymerase TPP Thiamine pyrophosphate 03 medical and health sciences Gene expression Genetics RBS Ribosomal Binding Site Molecular Biology Gene Regulation of gene expression Virulence Transcription termination Biochemistry (medical) AdoCbl adenosylcobalamine RNA SAH S-adenosylhomocysteine 5ʹ-UTRs 5ʹ-untranslated region SAM S-adenosylmethionine RNAT RNA thermometer biology.organism_classification FMN Flavin mononucleotide Metabolic pathway lcsh:Genetics 030104 developmental biology Riboswitches Bacterial pathogenicity Archaea CSPs Cold Shock Proteins |
| Zdroj: | Non-coding RNA Research, Vol 3, Iss 2, Pp 54-63 (2018) Non-coding RNA Research |
| ISSN: | 2468-0540 |
| Popis: | Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or key metabolites, changes in surrounding pH, and temperature shifts are the most important examples of such parameters. To elicit a proper response to such fluctuations, bacterial cells coordinate the expression of parameter-relevant genes. Although protein-mediated control of gene expression is well appreciated since many decades, RNA-based regulation has been discovered in early 2000s as a parallel level of regulation. Small regulatory RNAs have emerged as one of the most widespread and important gene regulatory systems in bacteria with rare representatives found in Archaea and Eukarya. Riboswitches and thermosensors are cis-encoded RNA regulatory elements that employ different mechanisms to regulate the expression of related genes controlling key metabolic pathways and genes of temperature relevant proteins including virulence factors. The extent of RNA contributions to gene regulation is not completely known even in well-studied models such E. coli and B. subtilis. In depth understanding of riboswitches is promising for opportunity to discover a narrow spectrum antibacterial drugs that target riboswitches of essential metabolic pathways. |
| Databáze: | OpenAIRE |
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