Low testosterone bioavailability is related to prostate cancer diagnose in patients submitted to prostate biopsy
Autor: | Jorge Huguet, Meritxell Pérez Márquez, Antonio Alcaraz, Ricardo Alvarez-Vijande, Lluis Peri, Agustín Franco, Eduardo García-Cruz, Marta Piqueras, Maria J. Ribal, Laura Izquierdo |
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Rok vydání: | 2011 |
Předmět: |
Male
PCA3 Nephrology medicine.medical_specialty Prostate biopsy Urology urologic and male genital diseases Cohort Studies Prostate cancer Prostate Sex Hormone-Binding Globulin Internal medicine medicine Humans Testosterone Prospective Studies Prospective cohort study Ultrasound High-Intensity Focused Transrectal Aged Digital Rectal Examination Retrospective Studies medicine.diagnostic_test business.industry Biopsy Needle Prostatic Neoplasms Organ Size Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure business |
Zdroj: | World Journal of Urology. 30:361-365 |
ISSN: | 1433-8726 0724-4983 |
DOI: | 10.1007/s00345-011-0741-9 |
Popis: | Relationship between prostate cancer (PCa) and testosterone (T) is controversial. Conflicting evidence has been published about T levels and development of PCa.(1) To determine the relationship between hormone levels and the diagnosis of PCa. (2) To specifically focus on the relationship between PCa and T in men classified as biochemically hypogonadal.Prospective analysis of 1,000 transrectal ultrasound guided prostate biopsies (5 + 5 cores biopsies) between September 2007 and January 2010 in one center. Indication for prostate biopsy was suspicion of PCa on the basis of elevated prostate-specific antigen (PSA) and/or digital rectal examination (DRE). Serum testosterone and sex hormones binding globulin (SHBG) were determined in these patients. Of 557 men, the data were sufficient for further analysis. Age, body mass index (BMI), smoking/drinking habits, PSA, free PSA, PSA density, prostate volume, number of previous biopsies, DRE, and hormone levels were prospectively recorded.No relationship was found between T and PCa (449 ± 167 ng/dL in PCa versus 437 ± 169 ng/dL in non-PCa). SHBG was significantly higher in patients with PCa (51 ± 27 ng/dL in PCa vs. 44 ± 18 ng/dL in non-PCa). In hypogonadal men, T levels correlated with the PCa (235 ± 95 ng/dL in men with PCa versus 270 ± 58 ng/dL in men without PCa, P = 0.004).T levels were comparable in men with and without PCa, but SHBG levels were significantly higher in men with PCa. In men with low T, the men with PCa had a lower serum T levels and a lower prostate volume than the men without PCa. |
Databáze: | OpenAIRE |
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