Clinical phenotype of bipolar disorder with comorbid binge eating disorder
| Autor: | Miguel L. Prieto, Mark A. Frye, Mohit Chauhan, Nicole Mori, Joanna M. Biernacka, Stacey J. Winham, Jennifer R. Geske, Alfredo B. Cuellar Barboza, Scott J. Crow, Susan L. McElroy, Lisa R. Seymour |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Comorbidity Article Body Mass Index Cost of Illness Binge-eating disorder medicine Prevalence Humans In patient Bipolar disorder Obesity Psychiatry Clinical phenotype business.industry Body Weight Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Suicide Phenotype Female business Binge-Eating Disorder Clinical psychology |
| Zdroj: | Journal of affective disorders. 150(3) |
| ISSN: | 1573-2517 |
| Popis: | To explore the relationship between binge eating disorder (BED) and obesity in patients with bipolar disorder (BP).717 patients participating in the Mayo Clinic Bipolar Biobank completed structured diagnostic interviews and questionnaires for demographic and illness-related variables. They also had weight and height measured to determine body mass index (BMI). The effects of BED and obesity (BMI≥30 kg/m(2)), as well as their interaction, were assessed on one measure of general medical burden and six proxies of psychiatric illness burden.9.5% of patients received a clinical diagnosis of BED and 42.8% were obese. BED was associated with a significantly elevated BMI. Both BED and obesity were associated with greater psychiatric and general illness burden, but illness burden profiles differed. After controlling for obesity, BED was associated with suicidality, psychosis, mood instability, anxiety disorder comorbidity, and substance abuse comorbidity. After controlling for BED status, obesity was associated with greater general medical comorbidity, but lower substance abuse comorbidity. There were no significant interaction effects between obesity and BED, or BMI and BED, on any illness burden outcome.There may have been insufficient power to detect interactions between BED and obesity.Among patients with BP, BED and obesity are highly prevalent and correlated, but associated with different profiles of enhanced illness burden. As the association of BED with greater psychiatric illness burden remained significant even after accounting for the effect of obesity, BP with BED may represent a clinically important sub-phenotype. |
| Databáze: | OpenAIRE |
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