Body height in paediatric inflammatory bowel diseases: A structural equation model analysis
| Autor: | Eleftheria Roma-Giannikou, Giorgos Chouliaras, Ioanna Panayotou, Aimilia Mantzou, Panagiota Pervanidou, George P. Chrousos, Nikolaos Tsilifis, Daphne Margoni, Christina Kanaka-Gantenbein |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Mediation (statistics) Hydrocortisone Clinical Biochemistry Nutritional Status Physiology Inflammation Systemic inflammation Biochemistry Short stature Structural equation modeling Body Mass Index 03 medical and health sciences 0302 clinical medicine Crohn Disease Humans Medicine Endocrine system Insulin-Like Growth Factor I Child Retrospective Studies Interleukin-6 business.industry General Medicine medicine.disease Body Height Malnutrition Cross-Sectional Studies 030104 developmental biology Colitis Ulcerative Female 030211 gastroenterology & hepatology medicine.symptom business Body mass index |
| Zdroj: | European Journal of Clinical Investigation. 48:e12969 |
| ISSN: | 0014-2972 |
| Popis: | Background Linear growth restriction is a unique feature of paediatric inflammatory bowel diseases (IBD), and reduced insulin-like growth factor (IGF-1) is a major determinant of short stature. We aimed to assess factors influencing somatic height in children suffering from IBD. Materials and methods This was a retrospective, cross-sectional study conducted after approval by Institutional authorities. Anthropometric data, disease-related factors, biochemical and clinical indices of inflammation and endocrine parameters were recorded and considered as explanatory covariates. A structural equation model analysis was utilized. Somatic height was the outcome of interest, and possible associations of explanatory covariates directly or through the mediation effect of IGF-1 were assessed. Results Systemic inflammation, as expressed by high-sensitivity intereukin-6 (IL-6), and nutritional status described by body mass index (BMI) were the pathways that significantly affected stature through the mediation effect of IGF-1. Cortisol showed a direct, positive and independent of IGF-1 association with height. Conclusions Insulin-like growth factor-1 is a key player in the process that results in impaired linear growth. Malnutrition and systemic inflammation have a restrictive action on growth by reducing circulating IGF-1. The positive relation of serum cortisol to height could correspond to suppressed pituitary-adrenal axis due to long-term use of glucocorticoids. |
| Databáze: | OpenAIRE |
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