P2-purinoceptors on postganglionic sympathetic neurones
| Autor: | Angelika Schobert, I. von Kügelgen, Klaus Starke, D. Stoffel |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Receptors Purinergic P2 business.industry General Neuroscience Presynaptic Terminals Action Potentials Sympathetic nerve In Vitro Techniques Inhibitory postsynaptic potential Rats Norepinephrine Adenosine Triphosphate Sympathetic Fibers Postganglionic medicine.anatomical_structure Adenine nucleotide P2 Purinoceptors medicine Excitatory postsynaptic potential Animals Heart Atria Axon business Receptor Neuroscience Intracellular |
| Zdroj: | Journal of Autonomic Pharmacology. 16:413-416 |
| ISSN: | 1365-2680 0144-1795 |
| DOI: | 10.1111/j.1474-8673.1996.tb00065.x |
| Popis: | 1. Postganglionic sympathetic neurones possess both excitatory and inhibitory P2-purinoceptors. 2. The mechanisms of action of excitatory P2-purinoceptors have recently been studied on cultured sympathetic neurones of the rat. The receptors mediate fast increases in intracellular Ca2+ levels and a release of noradrenaline. They are likely to belong to the neuronal types of P2X-purinoceptors and to be located on the sympathetic nerve cell bodies or their dendrites. 3. Inhibitory P2-purinoceptors have been shown to operate at sympathetic axon terminals in isolated tissues. Adenine nucleotides decreased the stimulation-evoked release of noradrenaline by activation of these receptors. The receptors are likely to belong to the group of G-protein-coupled P2Y-purinoceptors. They mediate a negative feedback in which co-transmitter ATP inhibits subsequent sympathetic transmitter release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text