Extended Sedentary Time Increases the Risk of All-Cause Death and New Cardiovascular Events in Patients With Diabetic Kidney Disease
| Autor: | Takushi Sugiyama, Yumi Mochi, Atsuhiko Kawabe, Atsuko Uema, Takashi Tomoe, Hajime Tamiya, Takanori Yasu, Yuki Nakatani, Masato Onozaki, Moeko Nagao, Megumi Hoshiai, Yusuke Akazawa, Yuma Tamura, Syusuke Mochi, Asuka Ueno, Nobuyuki Banba |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Diabetic Nephropathies Prospective Studies 030212 general & internal medicine Mortality Risk factor Prospective cohort study Stroke Aged Aged 80 and over business.industry Hazard ratio General Medicine Middle Aged medicine.disease Cardiovascular Diseases Female Hemodialysis Sedentary Behavior Cardiology and Cardiovascular Medicine business Kidney disease |
| Zdroj: | Circulation Journal. 84:2190-2197 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-20-0407 |
| Popis: | Background Sedentary behavior may be an independent risk factor for cardiovascular events. This study aimed to clarify the effects of extended sedentary time in patients with diabetic kidney disease (DKD) on the risk of all-cause death and new events.Methods and Results:A prospective cohort study was performed over 39 months. The study included 173 patients with DKD who completed the International Physical Activity Questionnaire (IPAQ) (101 men; mean age, 71±11 years); 37 patients (21.4%) were diagnosed with cardiovascular disease (CVD). New events were defined as all-cause death, cerebral stroke, or CVD requiring hospitalization or commencing hemodialysis (HD). Data were analyzed using a multivariate Cox proportional hazard regression model with variables, including sedentary time. There were 34 cases of new events during the observation period, including 4 cases of stroke, 20 cases of CVD, 4 cases of HD implementation, and 6 cases of death. Hazard ratio (HR) calculations for the new event onset group identified sedentary time as a significant independent variable. The independent variable that was identified as a significant predictor of new events was the sedentary time (60 min/day; HR: 1.23, 95% CI: 1.05-1.45, P=0.012). Conclusions Extended sedentary time increased the risk of new cardiovascular or renal events and/or all-cause death in patients with DKD. |
| Databáze: | OpenAIRE |
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