The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus
| Autor: | Stefan Bluml, J G McComb, Matthew Borzage, A. Saunders, J. Hughes, Kevin S. King |
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| Rok vydání: | 2021 |
| Předmět: |
Volunteers
Measurement variability medicine.medical_specialty business.industry Neuroimaging medicine.disease Magnetic Resonance Imaging Hydrocephalus Normal Pressure Corpus Callosum Normal pressure hydrocephalus Cohort Humans Medicine Dementia Biomarker (medicine) Radiology Nuclear Medicine and imaging In patient Letters Neurology (clinical) Radiology Alzheimer's disease business Aged |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a7294 |
| Popis: | Many patients with dementia may have comorbid or misdiagnosed normal pressure hydrocephalus, a treatable neurologic disorder. The callosal angle is a validated biomarker for normal pressure hydrocephalus with 93% diagnostic accuracy. Our purpose was to develop and evaluate an algorithm for automatically computing callosal angles from MR images of the brain.This article reports the results of analyzing callosal angles from 1856 subjects with 5264 MR images from the Open Access Series of Imaging Studies and the Alzheimer's Disease Neuroimaging Initiative databases. Measurement variability was examined between 2 neuroradiologists (The algorithm identified that 12.4% of subjects from these carefully screened cohorts had callosal angles of90°, a published threshold for possible normal pressure hydrocephalus. The intraclass correlation coefficient was 0.97 for agreement between neuroradiologists and 0.90 for agreement between manual and automatic measurement. The method was robust to different head orientations. The median coefficient of variation for repeat examinations was 4.2% (Q1 = 3.1%, Q3 = 5.8%). The simulated classification of normal pressure hydrocephalus versus Alzheimer using the automatic callosal angle had an accuracy, sensitivity, and specificity of 0.87 each.In even the most pristine research databases, analyses of the callosal angle indicate that some patients may have normal pressure hydrocephalus. The automatic callosal angle measurement can rapidly and objectively screen for normal pressure hydrocephalus in patients who would otherwise be misdiagnosed. |
| Databáze: | OpenAIRE |
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