Naps Reliably Estimate Nocturnal Sleep Spindle Density in Health and Schizophrenia
| Autor: | Dimitrios Mylonas, Erin Kohnke, Bengi Baran, Lin Zhu, Robert Stickgold, William G. Coon, Catherine Tocci, Dara S. Manoach, Mark Vangel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Cognitive Neuroscience Polysomnography Sleep spindle Nocturnal Audiology Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine mental disorders medicine Humans medicine.diagnostic_test business.industry Eye movement Electroencephalography General Medicine medicine.disease Sleep in non-human animals 030228 respiratory system Nocturnal sleep Schizophrenia Case-Control Studies Memory consolidation Female business Sleep 030217 neurology & neurosurgery |
| Zdroj: | J Sleep Res |
| Popis: | Sleep spindles, defining oscillations of non-rapid eye movement stage 2 sleep (N2), mediate memory consolidation. Spindle density (spindles/minute) is a stable, heritable feature of the sleep electroencephalogram. In schizophrenia, reduced spindle density correlates with impaired sleep-dependent memory consolidation and is a promising treatment target. Measuring sleep spindles is also important for basic studies of memory. However, overnight sleep studies are expensive, time consuming and require considerable infrastructure. Here we investigated whether afternoon naps can reliably and accurately estimate nocturnal spindle density in health and schizophrenia. Fourteen schizophrenia patients and eight healthy controls had polysomnography during two overnights and three afternoon naps. Although spindle density was lower during naps than nights, the two measures were highly correlated. For both groups, naps and nights provided highly reliable estimates of spindle density. We conclude that naps provide an accurate, reliable and more scalable alternative to measuring spindle density overnight. |
| Databáze: | OpenAIRE |
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