Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer
| Autor: | Lucía Cortejoso, Luis A. López-Fernández, María Sanjurjo, Fernando Escolar, María I. García, Pilar García-Alfonso, Eva González-Haba |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Genotype Organoplatinum Compounds Colorectal cancer medicine.medical_treatment Pharmacology toxicology Toxicology Irinotecan Polymorphism Single Nucleotide Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) Aged Retrospective Studies Pharmacology Aged 80 and over Chemotherapy business.industry DNA Middle Aged medicine.disease digestive system diseases Differential toxicity Oxaliplatin Toxicity Multivariate Analysis Camptothecin Female business Colorectal Neoplasms Pharmacogenetics Biomarkers medicine.drug |
| Zdroj: | Cancer chemotherapy and pharmacology. 71(6) |
| ISSN: | 1432-0843 |
| Popis: | Oxaliplatin or irinotecan is usually administered jointly with fluoropyrimidines in colorectal cancer patients treated with chemotherapy. Both drugs have different toxicity patterns. Biomarkers for predicting high-risk severe adverse reactions can help select the best treatment.A retrospective analysis of 106 colorectal cancer patients receiving an oxaliplatin-based treatment and 56 receiving an irinotecan-based treatment was performed. One copy number variant (GSTT1) and nine polymorphisms in irinotecan and oxaliplatin metabolism, transport or DNA repair genes (ABCB1, UGT1A1, XRCC1, ERCC1, ERCC2, GSTP1) were genotyped by SNaPshot, polymerase chain reactions' length fragments, or copy number assays.In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asthenia(OR = 0.047; 95 % CI = 0.004–0.493; P = 0.011) and Tallele of ABCB1 C3435T SNP was associated with a lower risk of diarrhea (OR = 0.177; 95 % CI = 0.034–0.919;P = 0.039), and individuals with two copies of GSTT1 gene had a lower risk for asthenia (OR = 0.093; 95 %CI = 0.011–0.794; P = 0.030). In oxaliplatin-treated patients, carriers of one or two T variants of Asn118Asn ERCC1 SNP had a lower risk for neutropenia(OR = 0.205; 95 % CI = 0.061–0.690; P = 0.01) [corrected].These biomarkers could help oncologists select the best treatment by reducing toxicity associated with irinotecan or oxaliplatin in colorectal cancer patients, thus increasing their quality of life. |
| Databáze: | OpenAIRE |
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