Effect of antiepileptic drug comedication on lamotrigine concentrations
| Autor: | Željka Petelin Gadže, Ivana Čajić, Mila Lovrić, Iva Klarica Domjanović, Nada Božina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Phenytoin Topiramate Adolescent antiepileptic drug comedication lamotrigine Fructose Lamotrigine Pharmacology Young Adult 03 medical and health sciences medicine Humans Potency Drug Interactions Trough Concentration Oxcarbazepine Aged Retrospective Studies Epilepsy Dose-Response Relationship Drug Triazines business.industry Valproic Acid General Medicine Carbamazepine Middle Aged Clinical Science 030104 developmental biology Anticonvulsants Drug Therapy Combination Female Phenobarbital business medicine.drug |
| Zdroj: | Croatian Medical Journal Volume 59 Issue 1 |
| ISSN: | 0353-9504 1332-8166 |
| Popis: | AIM: To estimate the effect size of concomitant antiepileptic therapy on the concentrations of lamotrigine, a drug often prescribed in combination with other antiepileptic drugs (AED), which can act as enzyme inducers or inhibitors. ----- METHODS: A total of 304 patients with epilepsy, aged 18-70 years, were divided into a lamotrigine monotherapy group and groups receiving lamotrigine with AEDs that act as enzyme inducers, enzyme inhibitors, or both. We compared lamotrigine monotherapy serum concentrations with those where lamotrigine was administered with a metabolic inhibitor valproate, metabolic inducers carbamazepine, oxcarbazepine, phenobarbital, phenytoin, or topiramate, and both an inducer and an inhibitor. ----- RESULTS: Comparison of trough lamotrigine monotherapy concentrations and lamotrigine polytherapy concentrations showed an almost similar median concentration in case of drug-inducers, and higher lamotrigine concentration in case of comedication with valproate as an inhibitor. A significant difference was confirmed after dose correction (P |
| Databáze: | OpenAIRE |
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