Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses
| Autor: | Graciela Andrei, Dominique Schols, Miklós Nagy, Rudi Wilfried Jan Pauwels, Masanori Baba, István Horváth, Jan Balzarini, Judit Györgyi-Edelényi, Raymund Machovich, Robert Snoeck, Myriam Witvrouw, E. De Clercq, Miklos Low, Johan Neyts, Mitsuaki Hosoya, Sándor Görög |
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| Rok vydání: | 1990 |
| Předmět: |
0301 basic medicine
biology Viral culture viruses Viral transformation General Medicine 030204 cardiovascular system & hematology biology.organism_classification medicine.disease_cause Semliki Forest virus Virology Virus Microbiology Oncolytic virus 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Herpes simplex virus Vesicular stomatitis virus Junin virus medicine |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 1:233-240 |
| ISSN: | 2040-2066 |
| DOI: | 10.1177/095632029000100402 |
| Popis: | The sulphated polymers, such as polyvinylalcohol sulphate (PVAS) and its co-polymer with acrylic acid (PAVAS), have proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, respiratory syncytial virus, Sindbis virus, Semliki Forest virus, Junin virus, Tacaribe virus, murine sarcoma virus and human immunodeficiency virus. They are not inhibitory to non-enveloped viruses, such as poliovirus and reovirus. The broad-spectrum antiviral effects of these compounds depend on their molecular weight and degree of sulphation. Pharmacokinetic studies in rabbits have indicated that after intravenous bolus injection the serum concentrations of these compounds decay biphasically, with an initial half-life of approximately 90-120 min. ispartof: Antiviral chemistry & chemotherapy vol:1 issue:4 pages:233-240 status: published |
| Databáze: | OpenAIRE |
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