Immunological Characterization of Peptide Mimetics of Carbohydrate Antigens in Vaccine Design Strategies
| Autor: | Gina Cunto-Amesty, Behjatolah Monzavi-Karbassi, Andrew Lees, Ping Luo, Thomas Kieber-Emmons |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Immunogen
Molecular Sequence Data Carbohydrates Priming (immunology) chemical and pharmacologic phenomena Bioengineering Peptide Applied Microbiology and Biotechnology DNA vaccination Immune system Antigen Antigens Neoplasm Vaccines DNA Amino Acid Sequence Pharmacology chemistry.chemical_classification Immunity Cellular General Immunology and Microbiology biology Molecular Mimicry food and beverages General Medicine Biochemistry chemistry biology.protein Antibody CD5 Peptides Biotechnology |
| Zdroj: | Biologicals. 29:249-257 |
| ISSN: | 1045-1056 |
| DOI: | 10.1006/biol.2001.0307 |
| Popis: | Targeting antigens which cannot be readily addressed by genetic vectors is a major challenge in vaccine design. The inter-conversion of carbohydrate antigens into peptide mimetic forms provides a means to broaden the immune response to carbohydrate antigens. Peptides that mimic carbohydrate antigens offer new possibilities to augment immune responses to such antigens that include inducing carbohydrate reactive T-cell responses. Peptide mimeotopes can be formulated in a variety of ways that include multiple antigen peptides (MAP) and as DNA vaccines that prime for different antibody isotypes. On the immunological side we observe that: (i) depending on the immunogen formulation peptide mimetics can be processed by either CD5+ or CD5− B cells; (ii) peptide mimeotope immunization can induce cross-reactive responses to multiple carbohydrate forms; (iii) priming with peptide mimeotopes can enhance carbohydrate immune responses upon boosting and (iv) immunization with peptide mimeotopes can induce carbohydrate reactive T cells. |
| Databáze: | OpenAIRE |
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