Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635 nm on Open Skin Wound Healing in Normal and Diabetic Rats
| Autor: | Peter Kruzliak, František Longauer, Kilík R, Martina Vidová, Lucia Lakyová, Ján Sabo, Kamila Lacjaková, Jozef Radoňak, Tomáš Vasilenko |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Skin wound Article Subject medicine.medical_treatment Urology lcsh:Medicine Radiation Dosage General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Neovascularization Collagen fibres medicine Animals Humans Leukocyte disorder Low-Level Light Therapy Low level laser therapy Skin Inflammation Wound Healing General Immunology and Microbiology business.industry Significant difference lcsh:R General Medicine Phototherapy Surgery Rats Immune System Diseases Molecular mechanism medicine.symptom Wound healing business Leukocyte Disorders Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2014/269253 |
| Popis: | Background and Objective.Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats.Materials and Methods.Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) Sprague–Dawley rats. AlGaInP (635 nm, wavelength; 5 J/cm2, daily dose) was used to deliver power densities of 1, 5, and 15 mW/cm2three times daily until euthanasia.Results.PMNL infiltration was lower in the irradiated groups (15 mW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5 mW/cm2and 15 mW/cm2groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15 mW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15 mW/cm2) was recorded on day six after injury compared to the control group.Conclusion.LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres. |
| Databáze: | OpenAIRE |
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