A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

Autor: Sungwook Choi, Hye Rim Lim, Yu Mi Shin, Sung Jean Park, Yun Lan Kim, Tae-Sung Koo, Seo Yun Kim, Eun Hee Jeon, Ki Bum Hong
Rok vydání: 2019
Předmět:
Zdroj: Chemical Communications. 55:10424-10427
ISSN: 1364-548X
1359-7345
DOI: 10.1039/c9cc04172a
Popis: The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biological matrix.
Databáze: OpenAIRE