Actinic Granuloma of the Conjunctiva: Case Series and Review of the Literature
| Autor: | Tatyana Milman, Zeba A. Syed, Vipin Goyal, Ralph C. Eagle, Brandon D. Ayres, Beeran Meghpara, Christopher J. Rapuano, Sebastian Heersink, Tejal Magan, Heather M. Skeens |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Keratoacanthoma medicine.medical_specialty Pinguecula Pterygium 03 medical and health sciences 0302 clinical medicine medicine Humans 030304 developmental biology Conjunctival squamous cell carcinoma Retrospective Studies 0303 health sciences Granuloma business.industry Episcleritis Actinic elastosis medicine.disease Dermatology eye diseases Ophthalmology Actinic granuloma 030221 ophthalmology & optometry Female Neoplasm Recurrence Local business Conjunctiva Scleritis |
| Zdroj: | American journal of ophthalmology. 229 |
| ISSN: | 1879-1891 |
| Popis: | Purpose To characterize the clinical and histopathologic features of actinic granuloma of the conjunctiva. Design Retrospective observational case series Methods Institutional pathology records between 2014 and 2020 were searched for all cases of conjunctival actinic granuloma. Information collected included age, sex, ocular and medical history, clinical findings, laboratory workup, treatment, follow-up, pathologic diagnosis, and histopathologic inflammation pattern. Results Eight eyes of 8 patients, 5 men and 3 women, with a median age of 43 years (mean 49, range 24-83) were identified. Clinical diagnosis was pterygium (n = 4, 50%), inflamed pterygium (n = 1, 13%), pterygium vs conjunctival squamous cell carcinoma (n = 1, 13%), episcleritis vs inflamed pinguecula (n = 1, 13%), and scleritis vs keratoacanthoma (n = 1, 13%). Of 5 lesions with follow-up information, none recurred following excision with a median follow-up of 9 weeks (mean 19 weeks, range 1-61 weeks). Allergy/atopy was documented in 4 of 7 (57%) patients with available medical information. There were no other systemic associations. Histopathologically, actinic granuloma was associated with pterygium (n = 6, 75%) and pinguecula (n = 2, 25%). All lesions were composed predominantly of histiocytes and a variable number of foreign body–type giant cells associated with a focus of severe actinic elastosis. The inflammatory pattern was giant cell (n = 4, 50%), sarcoidal (n = 2, 25%), histiocytic (n = 1, 13%), and combined histiocytic and sarcoidal (n = 1, 13%). Conclusion Conjunctival actinic granuloma has diverse clinical and histopathologic manifestations, which need to be distinguished from other autoimmune, neoplastic, and infectious etiologies. This lesion frequently occurs in pre-existing pterygium and pinguecula and may be associated with allergy and atopy. |
| Databáze: | OpenAIRE |
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