Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children
| Autor: | Rebecca L. Flores, Stacy R. Oliver, Frank Zaldivar, Jaime S. Rosa, Andria M. Pontello, Scott C. Graf, Milagros Ibardolaza, Pietro R. Galassetti |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Eotaxin
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Time Factors Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism VEGF receptors CD40 Ligand Anti-Inflammatory Agents Anti-inflammatory Proinflammatory cytokine Endocrinology Oxygen Consumption Internal medicine Interleukin-1alpha medicine Humans Immunologic Factors Sexual Maturation Exercise physiology Exercise duration Exercise Immunoassay biology business.industry Extramural Interleukin-6 Tumor Necrosis Factor-alpha Kinetics Physical Fitness Pediatrics Perinatology and Child Health Immunology biology.protein Exercise Test Female Inflammation Mediators business |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 20(12) |
| ISSN: | 0334-018X |
| Popis: | While acute changes in systemic pro-/antiinflammatory cytokines occur with exercise, individual kinetics during and following exercise remain unclear; particularly, information is scarce regarding children. This study investigated the exercise-induced kinetic profiles of major pro-/anti-inflammatory mediators in 21 healthy children (13.9 +/- 0.8 yr, 7 M/14 F). Exercise was 30 min of intermittent cycling at approximately 80% VO2max. Multiple blood samples were drawn at baseline, during, and following exercise for cytokines assay. IL-1alpha, IL-6, IL-17, IL-8, IP-10, MIP-1alpha, and MIP-1beta initially decreased (nadir: 14-19 min into exercise) and subsequently exceeded baseline levels (peaks: 20-24 min into exercise). TNF-alpha, IL-12p70, IL-1RA, IL-4, EGF, TGF-alpha, GM-CSF, Eotaxin, and MCP-1 were moderately and persistently decreased throughout. VEGF was unchanged; sCD40L was elevated during exercise and recovery. Our results indicate that key immunomodulators display non-linear, biphasic kinetic profiles in response to exercise, suggesting that detection of exercise-induced changes over baseline may depend on exercise duration and sampling timing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|