Radiation Therapy as Sole Management for Solitary Fibrous Tumors (SFT): A Retrospective Study From the Global SFT Initiative in Collaboration With the Sarcoma Patients EuroNet
| Autor: | Claudia Sangalli, Winan J. van Houdt, A.N. Scholten, Peter C. Ferguson, Anthony M. Griffin, Iris Walraven, Estelle Lecointe-Artzner, Mateusz Spałek, Stijn Krol, Thomas F. DeLaney, Rick L. Haas, Michiel A. J. van de Sande, Yen-Lin Chen, Shaine Zaidi, Silvia Stacchiotti, Rieneke G Moeri-Schimmel, Aisha Miah |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Solitary fibrous tumor Time Factors medicine.medical_treatment Kaplan-Meier Estimate Malignancy Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Metastasis Prospective cohort study Aged Proportional Hazards Models Retrospective Studies Radiation Proportional hazards model business.industry Sarcoma Retrospective cohort study Middle Aged medicine.disease Europe Radiation therapy Treatment Outcome Solitary Fibrous Tumors 030220 oncology & carcinogenesis Disease Progression Female Observational study business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 101:1226-1233 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2018.04.024 |
| Popis: | Purpose Solitary fibrous tumors (SFTs) are extremely rare mesenchymal malignancies. Given the lack of large prospective studies on radiation therapy (RT) with definitive and/or palliative intent in SFT patients, this retrospective study aimed to better define the benefit of RT in this disease. Methods and Materials A retrospective observational study was performed across 7 sarcoma centers. Clinical information was retrieved from all patients receiving RT without surgery over the course of their locally advanced and/or metastatic disease. Differences in treatment characteristics between subgroups were tested using analysis-of-variance tests. Local control (LC) and overall survival (OS) rates were calculated as time from the start of RT until local progression and death from any cause, respectively. Results Since 1990, a total of 40 patients were identified. RT was applied with definitive intent in 16 patients and with palliative intent in 24. The median follow-up period was 62 months. In patients treated with definitive RT (receiving approximately 60 Gy), the objective response rate was 67%. At 5 years, the LC rate was 81.3%, and the OS rate was 87.5%. In the case of palliative RT (typically 39 Gy), the objective response rate was 38%. The LC and OS rates at 5 years were 62.5% and 54.2%, respectively. In both subgroups, RT-associated toxicities were mild with predominantly grade 1 acute and late side effects. Conclusions This retrospective study suggests a clinically meaningful benefit for RT given with either definitive or palliative intent without surgery in SFT management. Prospective registries potentially in collaboration with patient advocacy groups are warranted to further assess the role of RT in patients with this rare malignancy. |
| Databáze: | OpenAIRE |
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