Treg programming and therapeutic reprogramming in cancer
| Autor: | Michel DuPage, Mariela Alejandra Moreno Ayala, Zehui Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology chemical and pharmacologic phenomena Lymphocyte Activation T-Lymphocytes Regulatory 03 medical and health sciences 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Cancer immunotherapy Review Series: Tregs in Cancer: Where are we now? Neoplasms medicine Tumor Microenvironment Immunology and Allergy Humans Receptor business.industry Effector Cancer hemic and immune systems Cell Differentiation medicine.disease 030104 developmental biology Phenotype Cancer research Tumor Escape Immunotherapy business Energy Metabolism Reprogramming Tumor immunology 030215 immunology Signal Transduction |
| Zdroj: | Immunology |
| ISSN: | 1365-2567 |
| Popis: | Overcoming the immunosuppressive tumour microenvironment is the major challenge impeding cancer immunotherapy today. Regulatory T-cells (Tregs) are prevalent in nearly all cancers and, as immunosuppressive regulators of immune responses, they are the principal opponents of cancer immunotherapy. However, disabling Tregs systemically causes severe autoimmune toxicity, hastening the need for more selective methods to target intratumoural Tregs. In this review, we discuss a burgeoning new modality to specifically target tumour-infiltrating Tregs (TI-Tregs) by reprogramming their functionality from immunosuppressive to immune stimulatory within tumours. As the basis for therapeutic selectivity of TI-Tregs, we will focus on the defining features of Tregs within cancer: their highly activated state controlled by the engagement of key surface receptors, their distinct metabolic programme, and their unique transcriptional programme. By identifying proteins and pathways that distinguish TI-Tregs from other Tregs in the body, as well as from the beneficial antitumour effector T-cells within tumours, we highlight mechanisms to selectively reprogramme TI-Tregs for the treatment of cancer. |
| Databáze: | OpenAIRE |
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