VEGF receptor inhibition slows the progression of polycystic kidney disease
| Autor: | Zhibin He, Robert W. Schrier, Y. Yin, Sandor Falk, Sarah Faubel, Jin K. Kim, Iram Zafar, Y. Tao, Charles L. Edelstein |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Nephrology Heterozygote medicine.medical_specialty Angiogenesis receptor inhibition Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vasculogenesis Internal medicine Polycystic kidney disease Animals Medicine RNA Catalytic RNA Messenger Receptor Cell Proliferation ADPKD 030304 developmental biology Polycystic Kidney Diseases 0303 health sciences vascular endothelial growth factor business.industry Cell growth Rats Inbred Strains Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Rats 3. Good health Vascular endothelial growth factor Disease Models Animal Kidney Tubules Receptors Vascular Endothelial Growth Factor Endocrinology chemistry 030220 oncology & carcinogenesis Disease Progression business Kidney disease |
| Zdroj: | Kidney International. 72:1358-1366 |
| ISSN: | 0085-2538 |
| Popis: | Although the receptors for vascular endothelial growth factor (VEGF) exert their effects on vasculogenesis and angiogenesis through receptors located on endothelial cells, recent studies have shown that these receptors are also present on renal tubular epithelial cells. We investigated the role of VEGF on increased tubule cell proliferation in the Han:SPRD heterozygous (Cy/+) rat model of polycystic kidney disease. The levels of VEGF in the kidneys and the serum, and the expression of the two receptors on tubules were increased in Cy/+ rats. These rats were given ribozymes that specifically inhibited VEGFR1 and VEGFR2 mRNA expression. Tubule cell proliferation within the cysts was significantly decreased in the ribozyme-treated animals leading to decreased cystogenesis, blunted renal enlargement, and prevented the loss of renal function. Our studies show that inhibition of VEGF function may be an important therapeutic option to delay the progression of polycystic kidney disease. |
| Databáze: | OpenAIRE |
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