SuperTCM:A biocultural database combining biological pathways and historical linguistic data of Chinese Materia Medica for drug development
Autor: | Saskia Preissner, Björn Oliver Gohlke, Kathleen Gallo, Robert Preissner, Lakshmi Seshadri, Andreas Eckert, Andrean Goede, Mathias Dunkel, Qiaofeng Chen, Renata Abel, Lena Springer |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Databases
Factual Phytochemistry (Ingredients) Databases Pharmaceutical Computer science KEGG pathways Materia medica Traditional Chinese medicine RM1-950 Network Pharmacology computer.software_genre International Classification of Diseases Animals Humans Chinese pharmacopoeia Medicine Chinese Traditional KEGG Medicinal plants Pharmacopoeias as Topic Pharmacology materia medica Database Drug discovery Traditional Chinese Medicine (TCM) Linguistics General Medicine Systems Integration Metabolism Drug development Therapeutics. Pharmacology computer Databases Chemical Drugs Chinese Herbal |
Zdroj: | Chen, Q, Springer, L, Gohlke, B O, Goede, A, Dunkel, M, Abel, R, Gallo, K, Preissner, S, Eckert, A, Seshadri, L & Preissner, R 2021, ' SuperTCM : A biocultural database combining biological pathways and historical linguistic data of Chinese Materia Medica for drug development ', Biomedicine and Pharmacotherapy, vol. 144, 112315 . https://doi.org/10.1016/j.biopha.2021.112315 Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112315-(2021) Biomedicine & Pharmacotherapy |
DOI: | 10.1016/j.biopha.2021.112315 |
Popis: | Aim of the study Botanicals used in Traditional Chinese Medicine (TCM) are a rich source for drug discovery and provide models for multi-component drug development. To facilitate the studies of the actions of TCM drugs and expand their applications, a comprehensive database is urgently required. Methods One online resource connects all the relevant data from multiple scientific sources and languages. Drug information from published TCM databases and the official Chinese Pharmacopoeia as well as specialized meta-websites such as Kew's Medicinal Plant Names Service was integrated on a higher level. Results Our database, SuperTCM, covers the aspects of TCM derived from medicinal plants, encompassing pharmacological recipes up to chemical compounds. It provides the information for 6516 TCM drugs (or "herbs") with 5372 botanical species, 55,772 active ingredients against 543 targets in 254 KEGG pathways associated with 8634 diseases. SuperTCM is freely available at http://tcm.charite.de/supertcm. |
Databáze: | OpenAIRE |
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