Can parasite-derived microRNAs differentiate active and inactive cystic echinococcosis patients?
| Autor: | Turkmen Ciftci, Ipek Baysal, Devrim Akinci, Samiye Yabanoglu-Ciftci, Okan Akhan, Serra Orsten, Yakut Akyön, Emre Ünal |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Echinococcus granulosus General Veterinary Cystic echinococcosis RNA General Medicine Biology biology.organism_classification MicroRNAs Metacestode Infectious Diseases Medical microbiology Real-time polymerase chain reaction Echinococcosis Insect Science microRNA Immunology medicine Animals Humans Parasite hosting Parasites Parasitology Biomarkers |
| Zdroj: | Parasitology Research. 121:191-196 |
| ISSN: | 1432-1955 0932-0113 |
| Popis: | Cystic Echinococcosis (CE) is a neglected zoonotic disease caused by the metacestode form of Echinococcus granulosus sensu lato. Non-invasive imaging techniques, especially ultrasound, are primarily used for CE diagnosis. MicroRNAs (miRNAs) are small, non-coding RNA molecules that act as post-transcriptional regulators in various biological processes. After identification of parasite-derived miRNAs, these miRNAs are considered to be potential biomarkers for diagnosis and follow-up. The focus of this research is to compare the expression profiles of certain parasite-derived miRNAs in CE patients with active and inactive cysts as well as healthy controls. Parasite-derived miRNAs, egr-let-7-5p, egr-miR-71a-5p, and egr-miR-9-5p, of inactive CE patients were found to be differentially expressed with 3.74-, 2.72-, and 20.78-fold change (p |
| Databáze: | OpenAIRE |
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