Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats
| Autor: | Marina Fernández, Carlos Libertun, Paula Arocena, Nadia Bourguignon, Victoria Lux-Lantos, Matías Rosa |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Aging CIENCIAS MÉDICAS Y DE LA SALUD Receptor expression Hypothalamus Thyroid Gland Thyrotropin PROLACTIN 010501 environmental sciences Endocrine Disruptors Toxicology 01 natural sciences Rats Sprague-Dawley 03 medical and health sciences Basal (phylogenetics) Phenols Thyrotropic cell In vivo Internal medicine Toxicología medicine Animals Benzhydryl Compounds Thyrotropin-Releasing Hormone THYROTROPE Cells Cultured 0105 earth and related environmental sciences Estrous cycle THYROTROPIN Dose-Response Relationship Drug urogenital system Chemistry Receptors Thyrotropin-Releasing Hormone Thyroid General Medicine THYROID HORMONE Prolactin Hypothalamic–pituitary–thyroid axis Medicina Básica 030104 developmental biology Endocrinology medicine.anatomical_structure Animals Newborn Pituitary Gland BISPHENOL A Female hormones hormone substitutes and hormone antagonists |
| Popis: | Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500 μg 50 μl−1 oil (B500), or 50 μg 50 μl−1 (B50), or 5 μg 50 μl−1 (B5). Controls were injected with 50 μl vehicle during the same period. Neonatal exposure to BPA did not modify TSH levels in PND13 females, but it increased them in adults in estrus. Serum T4 was lower in B5 and B500 with regards to Control, whereas no difference was seen in T3. No significant differences were observed in TRH, TSHβ and TRH receptor expression between groups. TSH release from PPC obtained from adults in estrus was also higher in B50 with regard to Control. In vitro 24 h pre-treatment with BPA or E2 increased basal TSH as well as prolactin release. On the other hand, both BPA and E2 lowered the response to TRH. The results presented here show that the neonatal exposure to BPA alters the hypothalamic pituitary-thyroid axis in adult rats in estrus, possibly with effects on the pituitary and thyroid. They also show that BPA alters TSH release from rat PPC through direct actions on the pituitary. Fil: Fernandez, Marina Olga. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Bourguignon, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Arocena, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Rosas, Nicolás Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Libertun, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina |
| Databáze: | OpenAIRE |
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