Isolation and structure of cephalostatins 10 and 11
| Autor: | Nigel D. Christie, Michael D. Williams, Jun-Ping Xu, Jean M. Schmidt, George R. Pettit, Michael R. Boyd, Dennis L. Doubek |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
food.ingredient
Magnetic Resonance Spectroscopy Stereochemistry Molecular Conformation Pharmaceutical Science Antineoplastic Agents Cephalodiscus Biology Crystallography X-Ray Analytical Chemistry food Chordata Nonvertebrate Drug Discovery Tumor Cells Cultured Animals Humans Spiro Compounds Pharmacology Cephalostatin 1 Organic Chemistry Nuclear magnetic resonance spectroscopy Indian ocean Complementary and alternative medicine Molecular Medicine Phenazines Steroids High field Drug Screening Assays Antitumor Cephalostatin Two-dimensional nuclear magnetic resonance spectroscopy Human cancer |
| Zdroj: | Journal of natural products. 57(1) |
| ISSN: | 0163-3864 |
| Popis: | Further investigation of antineoplastic constituents from the marine worm Cephalodiscus gilchristi, employing a 450 kg re-collection from the Indian Ocean (Southeast Africa), has led to isolation and structural determination of two previously undetected members of the cephalostatin series, designated cephalostatins 10 [4] and 11 [5]. Structural analyses were conducted primarily employing high field 2D nmr and high resolution mass spectral techniques. All the stereochemical assignments were deduced using the original X-ray crystal structure of cephalostatin 1 and ROESY 2D nmr methods. Both cephalostatins 10 and 11 strongly inhibited growth of a series of important human cancer cell lines. |
| Databáze: | OpenAIRE |
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