Knee osteoarthritis has doubled in prevalence since the mid-20th century
| Autor: | David T. Felson, Heli Maijanen, Steven Worthington, Ian J. Wallace, Robert Jurmain, Kimberly T. Wren, Robert J. Woods, Daniel E. Lieberman |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Urban Population Osteoarthritis History 21st Century Body Mass Index 03 medical and health sciences 0302 clinical medicine Cadaver Prevalence Medicine Humans Skeleton Aged 030203 arthritis & rheumatology Osteoarthritis Knee/epidemiology Multidisciplinary business.industry History 19th Century Biological Sciences History 20th Century Middle Aged Osteoarthritis Knee medicine.disease United States/epidemiology Obesity Confidence interval United States Eburnation Physical therapy Life expectancy Female business Body mass index 030217 neurology & neurosurgery Demography |
| Zdroj: | Wallace, I J, Worthington, S, Felson, D T, Jurmain, R D, Wren, K T, Maijanen, H, Woods, R J & Lieberman, D E 2017, ' Knee osteoarthritis has doubled in prevalence since the mid-20th century ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. 9332-9336 . https://doi.org/10.1073/pnas.1703856114 |
| DOI: | 10.1073/pnas.1703856114 |
| Popis: | Knee osteoarthritis (OA) is believed to be highly prevalent today because of recent increases in life expectancy and body mass index (BMI), but this assumption has not been tested using long-term historical or evolutionary data. We analyzed long-term trends in knee OA prevalence in the United States using cadaver-derived skeletons of people aged ≥50 y whose BMI at death was documented and who lived during the early industrial era (1800s to early 1900s; n = 1,581) and the modern postindustrial era (late 1900s to early 2000s; n = 819). Knee OA among individuals estimated to be ≥50 y old was also assessed in archeologically derived skeletons of prehistoric hunter-gatherers and early farmers (6000-300 B.P.; n = 176). OA was diagnosed based on the presence of eburnation (polish from bone-on-bone contact). Overall, knee OA prevalence was found to be 16% among the postindustrial sample but only 6% and 8% among the early industrial and prehistoric samples, respectively. After controlling for age, BMI, and other variables, knee OA prevalence was 2.1-fold higher (95% confidence interval, 1.5-3.1) in the postindustrial sample than in the early industrial sample. Our results indicate that increases in longevity and BMI are insufficient to explain the approximate doubling of knee OA prevalence that has occurred in the United States since the mid-20th century. Knee OA is thus more preventable than is commonly assumed, but prevention will require research on additional independent risk factors that either arose or have become amplified in the postindustrial era. |
| Databáze: | OpenAIRE |
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