Nano-sized titanium alloy particles inhibit the proliferation and promote the apoptosis of bone marrow mesenchymal stem cells in vitro
| Autor: | Kai‑Jin Guo, Wei Zheng, Qing‑He Geng, Tao Ma, Xiao‑Bo He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Cancer Research titanium alloy proliferation Cell Metal Nanoparticles Biochemistry Models Biological 03 medical and health sciences 0302 clinical medicine stomatognathic system Genetics medicine Alloys Animals Particle Size Molecular Biology Cells Cultured Cell Proliferation Titanium 030222 orthopedics Cell growth Chemistry Mesenchymal stem cell apoptosis Mesenchymal Stem Cells Articles Cell cycle equipment and supplies Molecular medicine In vitro Coculture Techniques Cell biology 030104 developmental biology medicine.anatomical_structure Oncology Apoptosis Molecular Medicine nanoparticles Aseptic processing Rabbits and mesenchymal stem cell Biomarkers |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Aseptic loosening of artificial joints is the leading cause of failure for patients who receive total joint arthroplasty. Prior reports indicate that bone marrow mesenchymal stem cells (BSMC) are critical in the stabilization of implanted artificial joints, and that deregulated interaction between BMSCs and artificial joint derived particles is a risk factor for aseptic loosening with an unknown mechanism. In the present study, the pathomechanisms whereby titanium and its alloy derived particles facilitate aseptic loosing were investigated in vitro. It was demonstrated that nano‑sized titanium alloy particles significantly inhibited the proliferation of BMSCs in a time and concentration dependent manner. Furthermore, it was demonstrated that the particles promoted the apoptosis of BMSCs in the same manner. Bax and Caspase‑3 expression of BMSCs were elevated when cultured with the particles. As BMSCs exhibit a critical role in the stabilization of artificial joints, the results of the present study may provide a novel direction for the management of aseptic loosening in clinics. |
| Databáze: | OpenAIRE |
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