Transcription factor 21 expression in injured podocytes of glomerular diseases
| Autor: | Mayumi Takahashi-Kobayashi, Satoshi Yamazaki, Joichi Usui, Kunihiro Yamagata, Pierre Ronco, Surya V. Seshan, Shuzo Kaneko, Tetsuya Kawamura, Misa Yaguchi |
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| Přispěvatelé: | Université de Tsukuba = University of Tsukuba, Weill Medical College of Cornell University [New York], Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Gestionnaire, Hal Sorbonne Université |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Nephrotic Syndrome Urinary system [SDV]Life Sciences [q-bio] Kidney Glomerulus 030232 urology & nephrology lcsh:Medicine Kidney development Biology Severity of Illness Index Article Podocyte 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Basic Helix-Loop-Helix Transcription Factors Animals Humans lcsh:Science Urinary Tract Transcription factor Multidisciplinary Kidney diseases Podocytes lcsh:R Middle Aged medicine.disease Actin cytoskeleton Rats [SDV] Life Sciences [q-bio] Actin Cytoskeleton Disease Models Animal Proteinuria 030104 developmental biology medicine.anatomical_structure Endocrinology Cell culture Apoptosis Nephrology lcsh:Q Female Nephrotic syndrome |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.11516. ⟨10.1038/s41598-020-68422-3⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-68422-3⟩ |
| Popis: | Transcription factor 21 (TCF21) is one of the essential transcription factors in kidney development. To elucidate its influence on glomerular disease, we have investigated TCF21 expression in human and rat kidney tissue, and its urinary concentration. Immunohistological analysis suggested the highest TCF21 expression in nephrotic syndrome along with the urinary protein level. Urinary TCF21 concentration in human showed a positive correlation with its podocyte expression level. In nephrotic rat models, TCF21 expression in podocytes increased along with the severity of nephrotic syndrome. Next, in vitro experiments using Tcf21-expressing murine podocyte cell line, we could observe some Tcf21-dependent effects, related with actin cytoskeleton dysregulation and apoptosis. Our study illustrated TCF21 expression changes in vivo and its in vitro-functional significance injured podocytes. |
| Databáze: | OpenAIRE |
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