Detection of a homologous series of C26-C38 polyenoic fatty acids in the brain of patients without peroxisomes (Zellweger's syndrome)
| Autor: | Phillip A. Sharp, H. Singh, A. Pollard, Alf Poulos, David W. Johnson, A. J. Fellenberg |
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| Rok vydání: | 1986 |
| Předmět: |
Chromatography
Gas Biology Mass spectrometry Microbodies Biochemistry Cerebrohepatorenal syndrome Mass Spectrometry Homologous series chemistry.chemical_compound medicine Humans Molecular Biology chemistry.chemical_classification Brain Diseases Zellweger syndrome Chemical ionization Liver Diseases Brain Infant Fatty acid Syndrome Cell Biology Peroxisome medicine.disease chemistry Fatty Acids Unsaturated Kidney Diseases Research Article Polyunsaturated fatty acid |
| Zdroj: | Biochemical Journal. 235:607-610 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj2350607 |
| Popis: | The brains of patients with inherited abnormalities in peroxisomal structure and function contain greatly increased proportions of a homologous series of unique polyenoic fatty acids with carbon chain lengths ranging from 26 to 38. Based on evidence by chemical ionization and electron impact mass spectrometry before and after catalytic hydrogenation, and argentation t.l.c., these lipids have been tentatively identified as 26:5, 28:5, 30:5, 30:6, 30:7, 32:5, 32:6, 32:7, 34:5 and 34:6 fatty acids. A further two fatty acids eluting at very high temperatures from gas chromatography columns have been tentatively identified on the basis of their chemical ionization mass spectra as 36:6 and 38:6 fatty acids. |
| Databáze: | OpenAIRE |
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