A proposed staging system for primary gastric lymphoma
| Autor: | Tetsuo Hayakawa, Satoshi Hase, Yasumasa Niwa, Masaya Shimodaira, Yoshihisa Tsukamoto, Tetsuro Nagasaka, Hidemi Goto |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Working Formulation Lymphoma Gastroenterology Stomach Neoplasms Internal medicine Medicine Humans Stage (cooking) Survival rate Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Stomach Middle Aged medicine.disease Primary tumor Combined Modality Therapy Survival Rate Lymphatic system medicine.anatomical_structure Oncology Lymphatic Metastasis Female Lymph Lymph Nodes business |
| Zdroj: | Cancer. 73(11) |
| ISSN: | 0008-543X |
| Popis: | Background. Although primary gastric lymphoma is the most common extranodal lymphoma, no specific staging system exists. Methods. The authors reviewed 98 cases histologically classified according to the Working Formulation, including low grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Survival rates were calculated by the Kaplan-Meier method according to T, N, and M of the general rules of the International Union Against Cancer TNM system. The definitions of these categories are as follows: T1, tumor invades the lamina propria or submucosa; T2, the muscularis propria; T3, the subserosa; T4, the serosa without invasion of adjacent structures; T5, adjacent structures; N0, no regional lymph node metastasis; N1, perigastric lymph nodes within 3 cm of the edge of the primary tumor; N2, perigastric lymph nodes more than 3 cm from the edge of the primary tumor or in lymph nodes along the left gastric, common hepatic, splenic, or celiac arteries; N3, paraaortic and hepatoduodenal lymph nodes and/or other intraabdominal lymph nodes; N4, beyond N3; M0, no distant metastasis; and M1, positive. Results. The overall 5-year survival rate was 83.5%; it was 100% in T1, 82.4% in T2, 84.2% in T3, 52.9% in T4, and 33.3% in T5; 93.9% in NO, 90.5% in N1, 66.2% in N2, and 44.4% in N3/N4; and 86.0% in MO and 25.0% in M1. Based on these results, the authors proposed a new staging system as follows: Stage I, T1/NO, N1/MO; Stage II, T1/N2/MO, T2,T3/NO,N1,N2/MO; Stage III, T4,T5/any N/MO, any T/N3, N4/MO; and Stage IV, any T/any N/M1. According to this system, the 5-year survival rate significantly decreased as the stage progressed: 100% in Stage I, 88.9% in Stage II, 52.1% in Stage III, and 25.0% in Stage IV. In Stages I and II, survival rates were not significantly different whether chemotherapy was done or not, whereas in Stage III all patients treated with surgery alone died. Conclusions. This staging system is useful for assessing prognosis of and deciding a therapeutic plan for primary gastric lymphoma. Cancer 1994; 73:2709–15. |
| Databáze: | OpenAIRE |
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