Therapy and Prevention of Hypertension of M-Shrsp
| Autor: | Y. Hamada, Kozo Okamoto, Y. Ohta, H. Shiokawa, T. Chikugo, Nobuko Morita |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Captopril Proline Angiotensin-Converting Enzyme Inhibitors Pharmacology Hypertension Malignant Organophosphorus Compounds Fish meal Animal model Rats Inbred SHR Internal medicine Internal Medicine Animals Medicine Juvenile human Life span business.industry Vascular lesion Hydralazine Diet Rats Cerebrovascular Disorders Disease Models Animal Endocrinology Hydralazine Hydrochloride Disease Susceptibility business Fish Flour medicine.drug |
| Zdroj: | Clinical and Experimental Hypertension. Part A: Theory and Practice. 13:1033-1042 |
| ISSN: | 0730-0077 |
| DOI: | 10.3109/10641969109042109 |
| Popis: | M-SHRSP rats appear to be a useful animal model for studying juvenile human malignant hypertension. Using M-SHRSP, the present study was conducted. Drugs selected for use were captopril, SQ 29,852 and hydralazine hydrochloride. The rats were also fed a 33% fish meal diet. When given separately, all three drugs were shown to be anti-hypertensive. However, using the fish meal diet combined with hydralazine was more effective than were any of the drugs given separately, while the effect of hydralazine combined with captopril or SQ 29,852 was even greater than that of the combined fish meal diet and hydralazine treatment. Some rats treated with captopril or SQ 29,852 separately were resistant to treatment, however even for these rats life spans were significantly prolonged and hypertensive vascular lesion incidence rates were drastically lowered. It was also found that even such vascular lesions as angionecrosis seemed to disappear with captopril or SQ 29,852 treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|