Renal response to angiotensin II is blunted in sodium-sensitive normotensive men
| Autor: | A. Titia Lely, Arnold H. Boonstra, Gerjan Navis, Frans Boomsma, Folkert W. Visser |
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| Přispěvatelé: | Internal Medicine, Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP) |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Renal function Hemodynamics BLOOD-PRESSURE Angiotensin-Converting Enzyme Inhibitors Blood Pressure Essential hypertension Kidney SALT-SENSITIVITY Renin-Angiotensin System chemistry.chemical_compound Enalapril Internal medicine Internal Medicine Medicine Humans Vasoconstrictor Agents ESSENTIAL-HYPERTENSION RISK Aldosterone Cross-Over Studies RECEPTOR CONVERTING-ENZYME business.industry Angiotensin II Sodium Sodium Dietary Effective renal plasma flow medicine.disease Endocrinology Blood pressure chemistry Regional Blood Flow Renal physiology Pulsatile Flow business SYSTEM |
| Zdroj: | American Journal of Hypertension, 21(3), 323-328. Oxford University Press American Journal of Hypertension, 21(3), 323-328. Oxford Univ. Press, New York |
| ISSN: | 0895-7061 |
| Popis: | BACKGROUNDIn hypertension, sodium sensitivity (SS) of blood pressure is associated with renal hemodynamic abnormalities related to increased activity of the renal renin-angiotensin aldosterone system (RAAS). The renal mechanisms of SS in normotensives are unknown. Therefore, we studied whether SS is related to renal hemodynamics and renal responsiveness to angiotensin II (Angll) in young healthy adults.METHODSBlood pressure (mean arterial pressure (MAP)) and renal function were measured in 34 healthy men after 1-week low-sodium diet (LS; 50 mmol Na+/24 h), 1-week high-sodium diet (HS; 200 mmol Na+/24h), and 1-week HS-ACEi (enalapril 20 mg/day).The responses of effective renal plasma flow (ERPF; I-131-Hippuran clearance) to graded infusion of Angll were assessed during each condition.RESULTSThe sodium-induced change in MAP ranged from -7to+14mmHg. SS (a sodium-induced increase in MAP > 3 mm Hg) was present in 13 subjects. ERPF was lower in SS subjects during LS and during HS-ACEi. The Angll-induced decrease in ERPF was blunted in SS on LS (-25 +/- 6 vs. -29 +/- 7% in sodium-resistant (SR) subjects, P CONCLUSIONSS normotensive subjects have a blunted renal response to exogenous Angll. This is ameliorated by ACE, supporting a role for inappropriately high intrarenal RAAS activity. As these findings cannot be attributed to subclinical renal hypertensive damage, high intrarenal RAAS activity and altered renal hemodynamics may be primary phenomena underlying SS. |
| Databáze: | OpenAIRE |
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