Breath Acetone Sensing Based on Single-Walled Carbon Nanotube-Titanium Dioxide Hybrids Enabled by a Custom-Built Dehumidifier
| Autor: | Nicholas G. Franconi, David N. Finegold, Courtney Fenk, Kara N. Bocan, Sean I. Hwang, Gregory J. Morgan, Miranda L. Vinay, Ervin Sejdic, David Rometo, Chen Hou-Yu, Sung Kwon Cho, James E. Ellis, Alexander Star, Michael A. Rothfuss, David L. White, Seth C. Burkert |
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| Rok vydání: | 2021 |
| Předmět: |
business.product_category
Bioengineering 02 engineering and technology Ketone Bodies 01 natural sciences Acetone chemistry.chemical_compound medicine Humans Instrumentation Breathalyzer Fluid Flow and Transfer Processes Chemiresistor Detection limit Titanium Chromatography Nanotubes Carbon Process Chemistry and Technology 010401 analytical chemistry 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Acetoacetic acid Breath gas analysis chemistry Breath Tests Ketone bodies Ketosis 0210 nano-technology business |
| Zdroj: | ACS sensors. 6(3) |
| ISSN: | 2379-3694 |
| Popis: | Acetone is a metabolic byproduct found in the exhaled breath and can be measured to monitor the metabolic degree of ketosis. In this state, the body uses free fatty acids as its main source of fuel because there is limited access to glucose. Monitoring ketosis is important for type I diabetes patients to prevent ketoacidosis, a potentially fatal condition, and individuals adjusting to a low-carbohydrate diet. Here, we demonstrate that a chemiresistor fabricated from oxidized single-walled carbon nanotubes functionalized with titanium dioxide (SWCNT@TiO2) can be used to detect acetone in dried breath samples. Initially, due to the high cross sensitivity of the acetone sensor to water vapor, the acetone sensor was unable to detect acetone in humid gas samples. To resolve this cross-sensitivity issue, a dehumidifier was designed and fabricated to dehydrate the breath samples. Sensor response to the acetone in dried breath samples from three volunteers was shown to be linearly correlated with the two other ketone bodies, acetoacetic acid in urine and β-hydroxybutyric acid in the blood. The breath sampling and analysis methodology had a calculated acetone detection limit of 1.6 ppm and capable of detecting up to at least 100 ppm of acetone, which is the dynamic range of breath acetone for someone with ketosis. Finally, the application of the sensor as a breath acetone detector was studied by incorporating the sensor into a handheld prototype breathalyzer. |
| Databáze: | OpenAIRE |
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